Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Chaiyawong, Nattawat; Ishizaki, Takahiro; Hakimi, Hassan; Asada, Masahito; Yahata, Kazuhide; Kaneko, O.

doi:10.1016/j.parint.2021.102479

Cited by 1 publication

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PfPH2 is an apically localized protein of the merozoite with a phosphoinositide-binding property, which controls exocytosis of only a subset of micronemes containing PfEBA proteins (45). Interestingly, in the rodent malaria parasite P. yoelii, APH controls the secretion not of EBA proteins but rather other MIC proteins, including AMA1 and MTRAP (29). This suggests that in Plasmodium, APH and PH2 might have a mutually exclusive role to regulate exocytosis of different sets of microneme vesicles.…”

Section: Microneme Exocytosismentioning

confidence: 99%

How Apicomplexa Parasites Secrete and Build Their Invasion Machinery

Cova

Lamarque

Lebrun

2022

Annu. Rev. Microbiol.

View full text Add to dashboard Cite

Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells. Invasion is a conserved process that relies on the timely and spatially controlled exocytosis of unique specialized secretory organelles termed micronemes and rhoptries. Microneme exocytosis starts first and likely controls the intricate mechanism of rhoptry secretion. To assemble the invasion machinery, micronemal proteins—associated with the surface of the parasite—interact and form complexes with rhoptry proteins, which in turn are targeted into the host cell. This review covers the molecular advances regarding microneme and rhoptry exocytosis and focuses on how the proteins discharged from these two compartments work in synergy to drive a successful invasion event. Particular emphasis is given to the structure and molecular components of the rhoptry secretion apparatus, and to the current conceptual framework of rhoptry exocytosis that may constitute an unconventional eukaryotic secretory machinery closely related to the one described in ciliates. Expected final online publication date for the Annual Review of Microbiology, Volume 76 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Section: Microneme Exocytosismentioning

confidence: 99%