Camel Milk Beneficial Effects on Treating Gentamicin Induced Alterations in Rats

Abstract

The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM. The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) and myeloperoxidase (MPO) activity while the antioxidant enzymes like superoxide dismutase (SOD) and glutathione s-transferase (GST) activity decreased significantly (P ≤ 0.05). Administration of CM significantly (P ≤ 0.05) inhibited the formation of MDA and activity of MPO and upregulated the antioxidant enzymes (SOD and GST) activity. The overall findings of this study demonstrated that pretreatment with CM gave protection against GM induced hepatic damage possibly by inhibiting oxidative stress and inflammation, and hence camel milk can be identified as a new therapeutic agent.

Camel Milk Ameliorates 5-Fluorouracil-Induced Renal Injury in Rats: Targeting MAPKs, NF-κB and PI3K/Akt/eNOS Pathways

“…These events can be regarded as compensatory mechanisms against renal damage since Kim-1 serves to suppress apoptosis and aids in tubular re-epithelization while NGAL behaves as an adhesion molecule that abrogates epithelial shedding [41]. Interestingly, current findings demonstrated that CM exerted renoprotective actions as confirmed by leveling-off these injury biomarkers; events that are in agreement with the reported CM attenuation of cisplatin- [21], Diabetes mellitus- [19] and gentamicin-induced nephrotoxicities [20]. …”

“…These observations support the premise that CM antioxidant features are implicated in the alleviation of 5-FU renal injury, likely via scavenging free radicals. These data are in accordance with the marked antioxidant features of CM in toxicant-induced renal damage [20, 21]. These beneficial effects have been attributed to CM significant content of the vitamins C and E along with the high levels of zinc, an essential element for SOD, and selenium, a component of selenoproteins and GPx enzyme [22, 23].…”

“…Several clinical and experimental studies have revealed the mitigating actions of CM against rheumatoid arthritis [13], inflammatory bowel disease [14], Diabetes mellitus [15], alcohol-induced hepatic injury [16], steatohepatitis [17] and wound healing [18]. More important, reports have indicated the efficacious role of CM in diabetes- [19], gentamicin- [20] and cisplatin-induced nephropathies [21]. Yet, whether CM can protect against 5-FU-evoked renal injury remains to be investigated.…”

Effect of Silymarin versus Silymarin and Green Coffee Extract on Thioacetamide Induced Liver Injury in Adult Male Albino Rats (Histological and Immunohistochemical Study)

“…Green coffee extract is a source of dietary antioxidants that may improve the quality of life.It is richin phenolic compounds (e.g. chlorogenic acid, caffeic acid andcaffeoyl tryptophan), cafestol, kahweol, nicotinic acid andcaffeine, the antioxidant and antimutagenic effects of which have been demonstrated in vitro.Antioxidants prevent free radical tissue damage byreducing or eliminating reactive oxygen species [39] .…”

Camel Milk with Pegylated Interferon Alfa-2a and Ribavirin for Treatment-Naive Chronic Hepatitis C Genotype 2/ 3: An Open-Label, Randomized Controlled Trial

“…Redwan et al (2014) showed that camel milk's lactoferrin might be one of the main components of CM that has anti-viral properties. They also stated that camel milk's lactoferrin is much more efficient than lactoferrin from human and cow's milk, which prevents the HCV to enter leukocytes and human HepG2 cells (17,18). El-Fakharany from Egypt (2012) showed that camel milk polyclonal antibody has destructive viral peptides and growth inhibitory effects yet human immunoglobulin and casein have not been affected (19).…”