CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education

Nunes, Paula; Diniz, Breno S.; Radanovic, Márcia; Abreu, Izabella Dutra de; Borelli, Danilo T.; Yassuda, Mônica Sanches; Forlenza, Orestes Vicente

doi:10.1002/gps.2038

Cited by 84 publications

(89 citation statements)

References 33 publications

(27 reference statements)

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“…Nunes et al 10 showed that CAMCOG presented a sensitivity of 64% and a specificity of 88%. One previous study, however, which explored psychometric properties (reliability, discriminative capacity and factorial structure) of the CAMCOG, found an excellent reliability of the individual subscales and high levels of sensitivity and specificity of the instrument in differentiating between demented and non-demented individuals 31 .…”

Section: Discussionmentioning

confidence: 99%

“…A higher rate of patients with MCI could be identified when the item scores were analyzed, which was not possible when only MMSE final scores were considered. ROC curve analyses were performed to determinate cutoff scores in the Cambridge Cognitive Examination (CAMCOG) for MCI patients, but discrimination between MCI subjects and controls with this method showed low accuracy 10 .…”

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confidence: 99%

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Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

Sudo

Alves

et al. 2010

Arq. Neuro-Psiquiatr.

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Objective: Cerebrovascular disease (CVD) is associated with cognitive deficits. This crosssectional study examines differences among healthy elderly controls and patients with vascular mild cognitive impairment (VaMCI) and vascular dementia (VaD) in performances on CAMCOG subscales. Method: Elderly individuals (n=61) were divided into 3 groups, according to cognitive and neuroimaging status: 16 controls, 20 VaMCI and 25 VaD. VaMCI and VaD individuals scored over 4 points on the Hachinski Ischemic Scale. Results: Significant differences in total CAMCOG scores were observed across the three groups (p<0.001). VaD subjects performed worse than those with VaMCI in most CAMCOG subscales (p<0.001). All subscales showed differences between controls and VaD (p<0.001). Performance on abstract thinking showed difference between VaMCI and controls (p<0.001). Vascular mild cognitive impairment (VaMCI) can be defined as a cognitive impairment of vascular etiology that does not fulfill criteria for dementia 1 . It has been proposed that vascular-related cognitive impairment exists throughout a continuum comprising VaMCI, vascular cognitive impairment no-dementia (Va-CIND) and vascular dementia (VaD) 2 . In a sample of cerebrovascular disease (CVD) patients with cognitive difficulties, Wentzel et al. 3 reported a 50% rate of conversion to dementia over a five-year period. The early detection of VaM-CI may allow therapeutic intervention designed to halt or delay the progression of vascular lesions so as to prevent the conversion to dementia 4,5 . Presently, the diagnosis of mild cognitive impairment (MCI) requires improvement in the sensitivity of conventional screening tests for dementia, since the rate of false-negative results is usually high for those individuals 6,7 . Studies attempting to increase such sensitivity have shown that a combination of different screening tests provides higher diagnostic accuracy compared to each test individually 8,9 . Diniz et al. 7 analyzed Mini-Mental State Examination (MMSE) subtests in a sample of MCI subjects and managed to identify distinct profiles of cognitive deficits among the MCI subtypes. A higher rate of patients with MCI could be identified when the item scores were analyzed, which was not possible when only MMSE final scores were considered. ROC curve analyses were performed to determinate cutoff scores in the Cambridge Cognitive Examination (CAMCOG) for MCI patients, but discrimination between MCI subjects and controls with this method showed low accuracy 10 . ConclusionIt was suggested that some cognitive domains might be specifically impaired in MCI subjects and these aspects could serve as differential markers to distinguish this condition from normal aging. Rodríguez et al. found that individuals diagnosed as MCI performed significantly worse than controls in CAMCOG subtests assessing various areas, with higher significance levels corresponding to the variables memory, abstract thinking and executive function 11 . In a previous study, Erkinjuntii et al. observed im...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

Sudo

Alves

et al. 2010

Arq. Neuro-Psiquiatr.

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“…7 In brief, patients were examined by clinicians specialized in the evaluation of cognitive disorders. The clinical assessment included the Cambridge Mental Disorders of the Elderly Examination (CAMDEX) interview, which yields the Cambridge Cognitive Examination (CAMCOG) and the MMSE scores.…”

Section: Clinical Assessmentmentioning

confidence: 99%

Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil

Abreu

Nunes

Diniz

et al. 2008

Rev. Bras. Psiquiatr.

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“…A confiabilidade interaferidor, avaliada por intermédio do coeficiente de correlação intraclasse, mostrou-se elevada entre as duas duplas de psiquiatras que aplicaram o instrumento, variando de 0,79 a 0,99 em uma dupla e de 0,67 a 1,0 na outra (p < 0,001). Por sua vez, Nunes et al 12 avaliaram o CAMCOG como teste de rastreamento para o diagnóstico do transtorno cognitivo leve e demência, em uma amostra clínica brasileira com média e alta escolaridade. Estes autores concluíram que o instrumento foi útil para diferenciar os indivíduos com transtorno cognitivo leve ou demência dos controles.…”

Section: Introductionunclassified

“…Os dois instrumentos, CAMCOG e CAMCOG-R, têm a maioria dos itens em comum; no entanto, a versão revisada, CAMCOG-R, conta com a vantagem de avaliar de maneira mais específica a função executiva, frequentemente comprometida nas demências, particularmente nas de natureza frontotemporal 12,13 .…”

Section: Introductionunclassified

Adaptação para o português do Cambridge Cognitive Examination-Revised aplicado em um ambulatório público de geriatria

2009

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Este artigo apresenta os resultados das quatro primeiras etapas (equivalências de conceito, de item, semântica e operacional) do processo de adaptação para o português do Cambridge Cognitive Examination-Revised (CAMCOG-R). O processo teve como base o modelo teórico proposto por Herdman et al., que, além das quatro etapas supracitadas, inclui as equivalências de mensuração e funcional, não avaliadas no presente trabalho. Um grupo de especialistas avaliou se todas as dimensões abarcadas pelo CAMCOG-R estavam presentes na realidade brasileira; duas traduções e retro-traduções foram realizadas, assim como a técnica de "grupos focais". A versão brasileira do CAMCOG-R (Br-CAMCOG-R) foi elaborada mantendo os 69 itens do instrumento original, com níveis variados de dificuldade. Esta versão foi então aplicada em 196 idosos, nos quais a duração média foi de 43 ± 9,4 minutos, e a média do escore total foi de 67 ± 14,8 pontos. Os achados do estudo mostram que a Br-CAMCOG-R pode ser uma ferramenta útil na avaliação cognitiva de idosos que foram positivos em testes de rastreamento.

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CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education

Cited by 84 publications

References 33 publications

Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil

Adaptação para o português do Cambridge Cognitive Examination-Revised aplicado em um ambulatório público de geriatria

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