Calvarial-orbital metastasis of prostate carcinoma which was diagnosed with sixth cranial nerve palsy

Abstract

Sixth nerve palsy is frequently due to infectious orbital lesions, trauma, elevated intracranial pressure, brainstem lesions, and vasculopathies. Here, we describe a rare cause of sixth cranial nerve (CN) palsy secondary to calvarial and orbital metastasis of prostate carcinoma. The diagnosis of the prostate carcinoma with sixth CN palsy is a very rare condition. A 66-year-old male patient presented with complaints of blurred vision, double vision, and inability to move outward in the right eye for 3 weeks. Magnetic resonance imaging revealed a right orbitocalvarial mass and the mass surgically removed completely. Pathologic findings were compatible with prostate adenocarcinoma metastasis. After surgical removal, significant improvement in sixth CN palsy was observed.

Cranial Nerve VI Palsy as Presenting Sign of Previously Undiagnosed Metastatic Prostate Adenocarcinoma to the Clivus

“…Typically, highly curable, prostate adenocarcinoma is the second leading cause of cancer-related death due to metastatic disease to the bone in 86% of the cases [2]. There has, however, been only 3 reported cases of metastatic prostate adenocarcinoma to the clivus [3][4][5]. Herein we present the case of a male who presented with a cranial nerve VI palsy with imaging showing an infiltrative skull base mass, who was ultimately diagnosed with prostate adenocarcinoma metastatic to the clivus.…”

Cranial Nerve VI Palsy as a Presenting Sign of Previously Undiagnosed Metastatic Prostate Adenocarcinoma to the Clivus

“…Typically, highly curable, prostate adenocarcinoma is the second leading cause of cancer-related death due to metastatic disease to the bone in 86% of the cases [2]. There has, however, been only 3 reported of metastatic prostate adenocarcinoma to the clivus [3][4][5]. Herein we present the case of a male who presented with a cranial nerve VI palsy with imaging showing an infiltrative skull base mass, who was ultimately diagnosed with prostate adenocarcinoma metastatic to the clivus.…”