Calprotectin (S100A8/A9), S100A12, and EDTA-resistant S100A12 complexes (ERAC) in primary Sjögren’s syndrome

Hh, Nordal; Jg, Brun; Ak, Halse; Tm, Madland; Fagerhol, Magne K.; Jönsson, Roland

doi:10.3109/03009742.2013.848930

Cited by 28 publications

(18 citation statements)

References 11 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61 Nordal et al 125 showed that CLP serum levels correlated with some indices of disease activity, especially with the fatigue score, but not with ESR and CRP; no association between CLP and arthritis was observed. CLP was found in saliva from SS patients at a concentration higher than in healthy subjects, and CLP levels were higher in the saliva than in the serum of SS patients.…”

Section: Sjö Gren Syndromementioning

confidence: 99%

“…128 The evidence that RAGE, a receptor of CLP, is overexpressed by myoepithelial cells in labial salivary glands of SS patients confirms the implication of CLP in the development of local inflammation. 129 No correlation has been found between CLP expression in the salivary glands and the lymphocytic focus score, 61,125 CLP concentration in the saliva might be a promising marker of local inflammatory activity in SS.…”

Section: Sjö Gren Syndromementioning

confidence: 99%

“…124,125 CLP might be locally released by inflammatory cells, as well as actively secreted by epithelial cells. 128 The evidence that RAGE, a receptor of CLP, is overexpressed by myoepithelial cells in labial salivary glands of SS patients confirms the implication of CLP in the development of local inflammation.…”

Section: Sjö Gren Syndromementioning

confidence: 99%

See 2 more Smart Citations

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

136

105

View full text Add to dashboard Cite

Calprotectin is an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues. Calprotectin seems to be more sensitive than CRP, being able to detect minimal residual inflammation and is a candidate biomarker in inflammatory diseases. High serum levels are associated with some severe manifestations of rheumatic diseases, such as glomerulonephritis and lung fibrosis. Calprotectin levels in other fluids, such as saliva and synovial fluid, might be helpful in the diagnosis of rheumatic diseases. Of interest is also the potential role of calprotectin as a target of treatment. AbstractCalprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse. There is evidence that a number of immunomodulators, including TNF-a inhibitors, may reduce calprotectin expression. S100A8 and S100A9 have a potential role as a target of treatment in murine models of autoimmune disorders, since the direct or indirect blockade of these proteins results in amelioration of the disease process. In this review, we will go over the biologic functions of calprotectin which might be involved in the etiology of rheumatic disorders. We will also report evidence of its potential use as a disease biomarker.

show abstract

Section: Sjö Gren Syndromementioning

confidence: 99%

Section: Sjö Gren Syndromementioning

confidence: 99%

See 1 more Smart Citation

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

136

105

View full text Add to dashboard Cite

show abstract

“…Numerous studies have shown that alterations of calprotectin level are associated with disease activity in patients with rheumatoid arthritis (RA) [8], Still’s disease [9], ankylosis spondylitis (AS) [10], psoriatic arthritis (PsA) [11], primary Sjögren’s syndrome (pSS) [12], juvenile idiopathic arthritis (JIA) [13] and systemic lupus erythematosus (SLE) [14]. Concentration of calprotectin was also elevated in patients with Crohn’s disease and ulcerative colitis [15], which is often used in diagnostics and monitoring of these illnesses.…”

mentioning

confidence: 99%

Calprotectin in rheumatic diseases: a review

2016

View full text Add to dashboard Cite

Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related protein 8 (MRP-8 or S100A8) and MRP-14 (or S100A9). At present, according to many authors, it is considered that calprotectin MRP8/14 is a potentially more sensitive biomarker of disease activity in rheumatoid disease than conventional inflammatory indices such as the erythrocyte sedimentation rate, C-reactive protein and others. A review of the literature on concentration of calprotectin in patients with some rheumatic diseases (rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still’s disease, systemic vasculitis, polymyalgia rheumatica, ankylosis spondylitis, systemic lupus erythematosus, and primary Sjögren’s syndrome) is presented.

show abstract

“…For example, high levels of calprotectin and S100A12 have been associated with inflammatory bowel disease and rheumatoid arthritis and high levels of S100A7 with inflammatory skin diseases (e.g., psoriasis, atopic dermatitis) [17, 30, 44]. Altered expression of S100 proteins also correlates with multiple autoimmune disorders including systemic lupus erythematosus, Still’s, and Sjogren’s [47–50]. Given the numerous associations to inflammation and infections, S100 proteins have been targeted for potential therapeutic effects [51].…”

Section: Introductionmentioning

confidence: 99%

S100 Proteins in the Innate Immune Response to Pathogens

Kozlyuk

Monteith

Garcia

et al. 2019

Methods in Molecular Biology

View full text Add to dashboard Cite

S100 proteins are distinct dimeric EF-hand Ca2+-binding proteins that can bind Zn2+, Mn2+, and other transition metals with high affinity at two sites in the dimer interface. Certain S100 proteins, including S100A7, S100A12, S100A8, and S100A9, play key roles in the innate immune response to pathogens. These proteins function via a “nutritional immunity” mechanism by depleting essential transition metals in the infection that are required for the invading organism to grow and thrive. They also act as damage-associated molecular pattern ligands, which activate pattern recognition receptors (e.g., Toll-like receptor 4 RAGE) that mediate inflammation. Here we present protocols for these S100 proteins for high-level production of recombinant protein, measurement of binding affinities using isothermal titration calorimetry, and an assay of antimicrobial activity.

show abstract

Calprotectin (S100A8/A9), S100A12, and EDTA-resistant S100A12 complexes (ERAC) in primary Sjögren’s syndrome

Cited by 28 publications

References 11 publications

Calprotectin in rheumatic diseases

Calprotectin in rheumatic diseases

Calprotectin in rheumatic diseases: a review

S100 Proteins in the Innate Immune Response to Pathogens

Contact Info

Product

Resources

About