Calprotectin, a leukocyte protein related to inflammation, in gingival crevicular fluid

Kido, Jun‐ichi; Nakamura, Teruo; Kido, Reiko; Ohishi, Keiji; Yamauchi, Noriyuki; Kataoka, Masatoshi; Nagata, Toshihiko

doi:10.1111/j.1600-0765.1998.tb02340.x

Cited by 41 publications

(30 citation statements)

References 22 publications

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“…The present data indicated that GCF calprotectin levels increased as the periodontal disease progresses from health to disease, but similar in G-AgP and CP. Our findings are consistent with the previous data showing the role of calprotectin as an inflammatory marker of periodontal disease [11,12,42,43]. Kaner et al [44] have demonstrated that GCF calprotectin levels are significantly correlated with the levels of periodontal inflammation and decreased after periodontal therapy in G-AgP patients.…”

Section: Discussionsupporting

confidence: 93%

“…It has been previously shown that calprotectin was present in human dental calculus and suggested that it might be derived from gingival crevicular fluid (GCF), saliva and dental plaque [10]. Studies have shown that calprotectin level in GCF from periodontitis patients is higher than that from healthy subjects and positively correlated with clinical and biochemical markers of periodontal inflammation [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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Abstract. Aim:The aim of the present study was to investigate gingival crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal telopeptide (NTx) levels in health along with different periodontal diseases. Material and methods: Twenty chronic periodontitis (CP), 20 generalized aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were included. Probing depth, clinical attachment level, plaque index and papillary bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to healthy subjects (p < 0.008). CP and G-AgP groups had similar, but higher levels compared to gingivitis groups (p < 0.008). CP and G-AgP groups had lower GCF osteocalcin total amount compared to gingivitis and healthy groups (p < 0.008). CP group had higher GCF NTx but lower osteocalcin total amount and osteocalcin/NTx ratio than the G-AgP group (p < 0.008). Conclusions: Our results suggest that elevated GCF calprotectin levels play a role as a reliable inflammatory marker in the pathogenesis of periodontal disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the abnormal bone turnover in periodontitis. Our data document for the first time the role of NTx in the pathogenesis of different periodontal diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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“…This concept was also supported and reflected by increases in certain granulocyte/monocytic granule proteins such as SA100A8. The myeloid‐related protein, S100A8 (calprotectin), is a product of neutrophils, monocytes, and activated macrophages and is a potent chemoattractant for neutrophils reported to be elevated within the gingival crevicular fluid (GCF) in gingivitis 11,12 . CX3CL1 (fractalkine) was upregulated 2.4‐fold and is chemotactic for T cells.…”

Section: Discussionmentioning

confidence: 99%

Gingival Transcriptome Patterns During Induction and Resolution of Experimental Gingivitis in Humans

Offenbacher

Barros

Paquette

et al. 2009

Journal of Periodontology

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A relatively small subset (11.9%) of the immune response genes analyzed by array was transiently activated in response to biofilm overgrowth, suggesting a degree of specificity in the transcriptome-expression response. The fact that this same subset demonstrates a reversal in expression patterns during clinical resolution implicates these genes as being critical for maintaining tissue homeostasis at the biofilm-gingival interface. In addition to the immune response pathway as the dominant response theme, new candidate genes and pathways were identified as being selectively modulated in experimental gingivitis, including neural processes, epithelial defenses, angiogenesis, and wound healing.

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“…Calcium binding on MRP‐8/14 leads to a conformational change in this protein and increases its thermal stability 9 . In periodontitis, as in other inflammatory diseases, MRP‐8/14 is produced by PMNs, monocytes, macrophages, and epithelial cells, which are involved in the early response of the immune system 7,10‐16 . During inflammatory disease, this protein is increased in different body fluids, such as plasma, synovial fluid, feces, and urine 17–19 .…”

mentioning

confidence: 99%

Comparative Analysis of Calcium‐Binding Myeloid‐Related Protein‐8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals

Haririan

Andrukhov

Pablik

et al. 2016

Journal of Periodontology

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Calprotectin, a leukocyte protein related to inflammation, in gingival crevicular fluid

Cited by 41 publications

References 22 publications

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Gingival Transcriptome Patterns During Induction and Resolution of Experimental Gingivitis in Humans

Comparative Analysis of Calcium‐Binding Myeloid‐Related Protein‐8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals

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