Comparative Analysis of Calcium‐Binding Myeloid‐Related Protein‐8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals

Abstract

MRP-8/14 in saliva might be a potential diagnostic parameter for periodontal disease.

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis

“…Also, calprotectin levels correlated positively with BOP, PD, and CAL. These findings are in line with previous reports of higher calprotectin levels in blood from patients with AgP 12,33 . Calprotectin is involved in neutrophil migration to inflammatory sites, 34 and its levels in plasma have been correlated with neutrophil count in patients with AgP 33 .…”

“…However, as opposed to what was found in serum, salivary calprotectin correlated significantly only with PI among the periodontal parameters. Increased levels of calprotectin in saliva have previously been reported in patients with AgP 12 . In addition, higher calprotectin has been observed in GCF in sites from naturally occurring and experimental gingivitis 35 .…”

Salivary neuropeptides, stress, and periodontitis

“…Between‐group differences regarding descriptive parameters were given in a previous investigation with the same study population . Results of the stress questionnaires were similar in all groups (Table ).…”

“…NPY might counteract the synthesis of interleukin (IL)‐6 after stimulation by periodontopathic bacteria, but thus far, this has been considered to explain the higher levels of NPY in the GCF of healthy sites . The authors suggest that substances with antimicrobial or anti‐inflammatory activities are released in abundance in periodontal disease to re‐establish a healthy state; this would also apply to NPY. However, NPY has not yet been investigated in human saliva in connection with periodontal disease, and data are limited to only one study of NPY in GCF …”

“…Stimulated whole saliva sampling was performed with a saliva extraction solution for 2 minutes from 8:00 am to 11:00 am. Detailed information about the study population, stratification of AgP versus CP, saliva, blood, and microbiologic sampling has been previously reported . Twenty different bacterial species were determined in saliva and subgingival plaque samples by polymerase chain reaction (see supplementary Appendix 1 in online Journal of Periodontology ).…”