Calorie Restriction— the SIR2 Connection

Guarente, Leonard; Picard, Frédéric

doi:10.1016/j.cell.2005.01.029

Cited by 723 publications

(600 citation statements)

References 70 publications

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“…75,76 Certain types of mutations in the IGF-1 pathway and SIR2/SIRT-1 play a central role in extending the longevity of an organism (yeast, worms, flies and mice). 77,78 Will the p53 pathway play a role in determining longevity in worms, flies, mice and humans? Longevity is also sexually dimorphic in some of these species.…”

Section: Questions About the P53 Pathway In A Larger Contextmentioning

confidence: 99%

The P53 pathway: what questions remain to be explored?

2006

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The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce proteins that communicate these stress signals to adjacent cells, prevent and repair damaged DNA and create feedback loops that enhance or attenuate p53 activity and communicate with other signal transduction pathways. Many questions remain to be explored in our understanding of how this network of genes plays a role in protection from cancers, therapy and integrating the homeostatic mechanisms of stress management and fidelity in a cell and organism. The goal of this chapter is to elucidate some of those questions and suggest new directions for this area of research.

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Section: Questions About the P53 Pathway In A Larger Contextmentioning

confidence: 99%

The P53 pathway: what questions remain to be explored?

2006

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“…It has been reported that the effect of CR is mediated by sirtuins in some organisms [19,20]. This implies that the level of a SIRT1-associated protein fluctuates in calorie-restricted animals.…”

Section: Increase In Liver Wrn Content Of Calorie-restricted Ratsmentioning

confidence: 99%

Sirtuin‐mediated deacetylation pathway stabilizes Werner syndrome protein

et al. 2008

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Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this effect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1-deficient mice. These results indicate that sirtuin-mediated deacetylation stabilizes WRN. Structured summary:MINT-6603869: ubiquitin (uniprotkb:P62988) physically interacts (MI:0218) with WRN (uniprotkb:Q14191) by pull down (MI:0096)

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“…6) SIRT1 has been reported to play a key role in stress response, metabolism and lifespan regulation. 7) Activation of SIRT1 protects mice from diet-induced obesity, metabolic disorders and oxidative injury, 8) while SIRT1 inactivation is associated with lipid accumulation, cell injury and diabetic nephropathy.…”

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confidence: 99%

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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Obesity-related renal diseases have been a worldwide issue. Effective strategy that prevents high fat-diet induced renal damage is of great significance. Resveratrol, a natural plant polyphenol, is famous for its antioxidant activity, cardioprotective effects and anticancer properties. However whether resveratrol can play a role in the treatment of renal diseases is unknown. In this study, we added resveratrol in normal glucose or high glucose medium and provide evidences that resveratrol protects against high-glucose triggered oxidative stress and cell senescence. Moreover, mice were fed with standard diet, standard diet plus resveratrol, high-fat diet or high-fat diet plus resveratrol for 3 months, and results show that resveratrol treatment prevents high-fat diet induced renal pathological damage by activating SIRT1, a key member in the mammalian sirtuin family that response to calorie restriction life-extension method. This research confirms the potential role of resveratrol in the treatment of renal diseases and may provide an effective and convenient method to mimic the beneficial effects of calorie restriction.

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Calorie Restriction— the SIR2 Connection

Cited by 723 publications

References 70 publications

The P53 pathway: what questions remain to be explored?

The P53 pathway: what questions remain to be explored?

Sirtuin‐mediated deacetylation pathway stabilizes Werner syndrome protein

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

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