Caloric restriction promotes beta cell longevity and delays aging and senescence signatures.
Rafael Arrojo e Drigo,
Cristiane dos Santos,
Shristi Shrestha
et al.
Abstract:Caloric restriction (CR) extends organismal lifespan and health span by improving glucose homeostasis mechanisms. How CR affects organellar structure and function of pancreatic beta cells over the lifetime of the animal remains unknown. Here, we used single nucleus transcriptomics to show that CR increases the expression of genes for beta cell identity, protein processing, and organelle homeostasis. Gene regulatory network analysis link this transcriptional phenotype to transcription factors involved in beta c… Show more
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