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citations
Cited by 57 publications
(55 citation statements)
references
References 73 publications
(85 reference statements)
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“…The first test is the EPM. We used EPM to evaluate anxiety of the mice (Bachstetter et al, 2014 ; Parikh et al, 2016 ), which was also performed at Rodent Behavioral Core (RBC) at the UK. The EPM consists of two open and two closed arms elevated 100 cm above the floor.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The first test is the EPM. We used EPM to evaluate anxiety of the mice (Bachstetter et al, 2014 ; Parikh et al, 2016 ), which was also performed at Rodent Behavioral Core (RBC) at the UK. The EPM consists of two open and two closed arms elevated 100 cm above the floor.…”
Section: Methodsmentioning
confidence: 99%
“…The third test is the RAWM, which is used to measure both spatial working memory and spatial reference memory (Arendash et al, 2001 ; Sood et al, 2007 ; Parikh et al, 2016 ). The RAWM task was conducted in the RBC at the UK as described previously (Guo et al, 2015 ), following a 2-day testing paradigm.…”
Section: Methodsmentioning
confidence: 99%
“…Such restriction was found to decrease body mass and normalize blood glucose, insulin, and leptin levels in obese animals and humans. In addition to effects on peripheral tissues, DR improves the operation of the central nervous system and weakens symptoms of age-related neurodegenerative disorders in rodent models [1][2][3][4][5][6][7]. There are two different approaches to model DR with rodents.…”
Section: Overweight and Obesity Became The Worldwide Epidemic Resultimentioning
confidence: 99%
“…In rodent models, CR leads to beneficial metabolic changes, protection from oxidative stress, neurotrophic factor production, increased autophagy, and neurogenesis 46 49 . CR also promotes the maintenance of cerebral blood flow and white matter integrity with age 50 , 51 . While CR has been demonstrated to improve spatial learning and memory in aged mice 51 , global effects on cognition remain unresolved, as CR failed to improve other hippocampal-dependent cognitive processes 52 54 .…”
Section: Systemic Interventions: Caloric Restriction Exercise Parabmentioning
confidence: 99%
“…CR also promotes the maintenance of cerebral blood flow and white matter integrity with age 50 , 51 . While CR has been demonstrated to improve spatial learning and memory in aged mice 51 , global effects on cognition remain unresolved, as CR failed to improve other hippocampal-dependent cognitive processes 52 54 . It is suggested that such inconsistent results could be due to the varied macronutrient ratios in CR regimes, the age of CR onset, and the metabolic heterogeneity of the diverse cell types in the hippocampus 55 57 .…”
Section: Systemic Interventions: Caloric Restriction Exercise Parabmentioning
confidence: 99%