2017
DOI: 10.3389/fnagi.2017.00298
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Abstract: Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain metabolic and vascular functions occur decades before the onset of cognitive impairments, and these reductions are highly associated with low-grade, chronic inflammation developed in the brain over time. Interestingly, recent findings suggest that the gut microbiota may… Show more

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Cited by 91 publications
(56 citation statements)
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References 115 publications
(141 reference statements)
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“…Higher levels of Prevotellaceae were evident in APOE3/E3 carriers relative to other genotype subgroups, while higher levels of Ruminococcaceae were correlated with the APOE2/E3 genotype (Figure 1 and Table S3) relative to APOE4 carriers. Similar associations were observed in APOE-TR transgenic animals with an increase in Prevotellaceae abundance in APOE3 young mice compared to APOE4 young mice in this study and an increase of Ruminococcaceae in APOE2 mice compared to APOE4 and APOE3 mice (Parikh et al, 2017). Interestingly, loss of these bacteria has been reported to negatively correlate with neurodegenerative disorders.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…Higher levels of Prevotellaceae were evident in APOE3/E3 carriers relative to other genotype subgroups, while higher levels of Ruminococcaceae were correlated with the APOE2/E3 genotype (Figure 1 and Table S3) relative to APOE4 carriers. Similar associations were observed in APOE-TR transgenic animals with an increase in Prevotellaceae abundance in APOE3 young mice compared to APOE4 young mice in this study and an increase of Ruminococcaceae in APOE2 mice compared to APOE4 and APOE3 mice (Parikh et al, 2017). Interestingly, loss of these bacteria has been reported to negatively correlate with neurodegenerative disorders.…”
Section: Discussionsupporting
confidence: 87%
“…In addition, lower relative abundance of Proteobacteria were seen in APOE4-TR young mice when compared to the APOE3-TR young mice (Table S4 and Figure S6). Although no significant difference was found in aggregated Firmicute or Bacteroidetes phylum abundance between APOE genotypes, we observed an increase in Firmicutes/Bacteroidetes ratio in old mice when compared to young mice (p < 0.001, Figure S7), in agreement with a previous C57BL/6N mouse study (Hoffman et al, 2017). At the order level, Deferribacterales abundance in combined age groups was significantly higher in the APOE4-TR mice compared to the APOE3-TR mice.…”
Section: Difference In Murine Gut Microbiota Composition Between Apoesupporting
confidence: 91%
“…Simultaneously, fluctuation of gut microbiome was also affected by aging. For example, the ratio of Firmicutes/Bacteroidetes and the abundance of g-Akkermansia, which is considered to maintain the integrity of the intestinal barrier, were changed along with aging [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…A large number of studies have revealed the remarkable effects of free fatty acid metabolism on brain circulation, structure, and function at different ages [50]. According to some studies [51,52], old mice display significantly increased levels of both amino acids and fatty acids, which are closely associated with AD biomarkers, compared to young mice. In the intestinal microbiome analyses, the Firmicutes/Bacteroidetes ratio and alpha diversity were increased in older mice.…”
Section: Resultsmentioning
confidence: 99%