Californium-252 and Hypoxyradiotherapy in Treatment of Advanced Carcinoma of the Cervix Uteri

Preoperative Hypoxyradiotherapy of Colorectal Carcinoma

“…It is necessary to point out that this is the first significant success in a 40-year effort to develop a procedure to be used in clinical practice, that modifies the negative effects of gamma radiation. The results of a study on hypoxyradiotherapy of pelvic tumors, including carcinoma of the cervix uteri, showed a dose modification factor (DMF) of 1.5 compared to conventional radiotherapy [24,25]. In a study on conventional externalbeam radiotherapy of cervical carcinoma, including the paraaortic lymphatic chain, a 60-Gy dose led to a considerable number of serious treatment complications and an increased mortality [31]; the same dose administered in acute hypoxia will cause no higher complication or mortality rate.…”

“…In a study on conventional externalbeam radiotherapy of cervical carcinoma, including the paraaortic lymphatic chain, a 60-Gy dose led to a considerable number of serious treatment complications and an increased mortality [31]; the same dose administered in acute hypoxia will cause no higher complication or mortality rate. Indeed, in comparison with the standard dose of 40 Gy applied under normal oxygenation conditions, administration of a 60-Gy dose in acute hypoxia paradoxically led to significantly less acute manifestations of postirradiation syndrome of the gastrointestinal tract (anorexia, nausea, and vomiting) and did not increase early or late complications of radiotherapy [25].…”

“…Theoretical assumptions of differential radioprotection by acute hypoxia to tumor and normal tissues have been verified experimentally [17,22,33,39] as well as clinically [1,23,24,[25][26][27][28]. Thus, induction of acute hypoxia has been introduced as a safe procedure allowing administration of radiation doses greater than the tolerance limits of normoxic tissues.…”

Remote Afterloading for Neutron Brachytherapy Using Californium-252

“…The results of neutron brachytherapy treatment of cervical cancer and tumors of the oral cavity, using 252 Cf nuclide, show the potential to reach 80% local control of advanced tumors [4,5,9,11], as a consequence of breaking down the tumor resistance against conventional photon irradiation.…”

Hypoxic Versus Normoxic External-Beam Irradiation of Cervical Carcinoma Combined with Californium-252 Neutron Brachytherapy

“…Theoretical assumptions of differential radioprotection by acute hypoxia to tumor and normal tissues have been verified experimentally [21,29,45,52], as well as clinically [1,28,30,37,40,42,43].…”