Calculation of Intracellular Aluminum Concentration in Neurofibrillary Tangle (Nft) Bearing and NFT-Free Hippocampal Neurons of Als/Parkinsonism-Dementia(pd) of Guam Using Laser Microprobe Mass Analysis(lamma)

Perl, D. P.; Munoz-Garcia, D.; Good, Paul F.; Pendlebury, William W.

doi:10.1097/00005072-198605000-00195

Cited by 15 publications

(3 citation statements)

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“…One is the neurotoxic effects of the indigenous cycad plant, seeds of which are primarily used as a food source. The other is aluminum toxicity, due to calcium deficiency and subsequent secondary hypoparathyroidism resulting in the underlying pathology [20,33,54,55].…”

Section: Risk Factorsmentioning

confidence: 99%

“…However, recent studies on Guam have shown adequate calcium and magnesium content of water and food grown in the soil areas of Umatac, where ALS/PDC is particularly prevalent [60]. There is evidence that aluminum is increased in brains of patients with ALS/PDC [55,61]. What, if any, role this plays in the etiology and pathogenesis is unknown.…”

Section: Risk Factorsmentioning

confidence: 99%

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Neuroepidemiologic Research Initiatives on Guam: Past and Present

Wiederholt

1999

Neuroepidemiology

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Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the etiology of these invariably fatal diseases. Over the same time period, the incidence of ALS has decreased dramatically, the incidence of PDC has decreased, but to a lesser degree, and age at onset has shifted to a later age by about 1 decade. Almost 50% of demented patients present without the classical Parkinsonian features of PDC, and the morphological picture has changed. Results of past and present research initiatives are reviewed.

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Section: Risk Factorsmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Neuroepidemiologic Research Initiatives on Guam: Past and Present

Wiederholt

1999

Neuroepidemiology

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“…33,35 Using this technology, we have begun to study the elemental constituents of tangle-bearing and tangle-free neurons of specimens derived from Guamanian ALS and tangle-free native controls. 33,35,36 While these studies are preliminary in nature, we have shown evidence of selective accumulation of aluminum within the tangle-bearing neurons of several of these Guamanian cases (Figures 1, 2).…”

Section: Laser Microprobe Mass Analysismentioning

confidence: 76%

Aluminum Neurotoxicity — Potential Role in the Pathogenesis of Neurofibrillary Tangle Formation

Perl

Pendlebury

1986

Can. J. Neurol. Sci.

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Abstract:Alzheimer's disease is a progressive neurodegenerative disease characterized neuropathologically by the development of large numbers of neurofibrillary tangles in certain neuronal populations of affected brains. This paper presents a review of the available evidence which suggests that aluminum is associated with Alzheimer's disease and specifically with the development of the neurofibrillary tangle. Aluminum salts innoculated into experimental animals produce neurofilamentous lesions which are similar, though not identical, to the neurofibrillary tangle of man. Although a few reports have suggested evidence of increased amounts of aluminum in the brains of Alzheimer's disease victims, such bulk analysis studies have been difficult to replicate. Using scanning electron microscopy with x-ray spectrometry, we have identified accumulations of aluminum in neurofibrillary tangle-bearing neurons of Alzheimer's disease. Similar accumulations have been identified in the neurofibrillary tangle-bearing neurons found in the brains of indigenous natives of Guam who suffer from parkinsonism with dementia and amyotrophic lateral sclerosis. This ongoing research still cannot ascribe a causal role of aluminum in the pathogenesis of neurofibrillary tangle formation; however, it does suggest that environmental factors may play an important part in the formation of this abnormality.

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Is Exposure to Aluminum a Risk Factor for the Development of Alzheimer Disease?—Yes

Forbes¹,

Hill²

1998

Arch Neurol

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Calculation of Intracellular Aluminum Concentration in Neurofibrillary Tangle (Nft) Bearing and NFT-Free Hippocampal Neurons of Als/Parkinsonism-Dementia(pd) of Guam Using Laser Microprobe Mass Analysis(lamma)

Cited by 15 publications

References 0 publications

Neuroepidemiologic Research Initiatives on Guam: Past and Present

Neuroepidemiologic Research Initiatives on Guam: Past and Present

Aluminum Neurotoxicity — Potential Role in the Pathogenesis of Neurofibrillary Tangle Formation

Is Exposure to Aluminum a Risk Factor for the Development of Alzheimer Disease?—Yes

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