Calcul numérique de la déformation mécanique d'un modèle de cellule endothéliale

Wache, P.; Wei, Xiong; Maurice, G.; Lucius, M.; Stoltz, Jean‐François

doi:10.1016/s1620-7742(00)00009-x

Cited by 2 publications

(3 citation statements)

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“…It is suggested that this activates receptors correspondingly, which could reflect the non-homogenous nature of EC regulation [108]. These studies on cellular-level hemodynamics reveal that ECs are subjected to different forces depending on their shape.…”

Section: Endothelial Cells Remodeling and Multi-scale Hemodynamic Modmentioning

confidence: 92%

Multi-scale modeling of hemodynamics in the cardiovascular system

Liang

Wong

et al. 2015

Acta Mech. Sin.

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The human cardiovascular system is a closedloop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study: recent progress of patient-specific hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling.

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Section: Endothelial Cells Remodeling and Multi-scale Hemodynamic Modmentioning

confidence: 92%

Multi-scale modeling of hemodynamics in the cardiovascular system

Liang

Wong

et al. 2015

Acta Mech. Sin.

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show abstract

“…[49][50][51][52] The maximum shear stress values are, however, lower than those obtained in computational studies. 36,52 In those studies, atomic force microscopy (AFM) or fluorescence imaging was used to measure cell topography and, in turn, generate computational grids for the endothelial cells. The computational results showed maximum shear stress values as high as three times that of the average applied shear of 10 dyn/cm 2 .…”

Section: B Shear Stress and Pressure Variationsmentioning

confidence: 99%

“…34 More recently, atomic force microscopy (AFM) was used to measure surface topography of ECs subjected to shear, and shear at the sub-cellular scale was then back calculated using CFD. 31,35,36 While this was a very important contribution, the coupling between mechanics and biochemistry remained elusive. Indeed, the vast majority of research involving shear stress effects on atherosclerosis has used the bulk shear in the vessel or, at best, the shear stress as a function of position on a plaque.…”

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confidence: 99%

In vitro measurements of hemodynamic forces and their effects on endothelial cell mechanics at the sub-cellular level

et al. 2018

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This paper presents micro-particle tracking velocimetry measurements over cultured bovine aortic endothelial cell monolayers in microchannels. The objective was to quantify fluid forces and cell morphology at the sub-cellular scale for monolayers subjected to steady shear rates of 5, 10, and 20 dyn/cm 2. The ultimate goal of this study was to develop an experimental methodology for in vitro detailed study of physiologically realistic healthy and diseased conditions. Cell topography, shear stress, and pressure distributions were calculated from sets of velocity fields made in planes parallel to the microchannel wall. For each experiment, measurements were made in 3 h intervals for 18 h. It was found that there is a three-dimensional change in cell morphology as a result of applied shear stress. That is, cells flatten and become more wedge shaped in the stream direction while conserving volume by spreading laterally, i.e., in the cross-stream direction. These changes in cell morphology are directly related to local variations in fluid loading, i.e., shear stress and pressure. This paper describes the first flow measurements over a confluent layer of endothelial cells that are spatially resolved at the sub-cellular scale with a simultaneous temporal resolution to quantify the response of cells to fluid loading.

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Calcul numérique de la déformation mécanique d'un modèle de cellule endothéliale

Cited by 2 publications

References 0 publications

Multi-scale modeling of hemodynamics in the cardiovascular system

Multi-scale modeling of hemodynamics in the cardiovascular system

In vitro measurements of hemodynamic forces and their effects on endothelial cell mechanics at the sub-cellular level

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