Calciumstoffwechsel und Citronens�ure

Klinke, K.; Schillert, Brigitte

doi:10.1007/bf00438795

Cited by 8 publications

(1 citation statement)

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“…'2 14,28,29 Although still somewhat controversial, the recent work has provided increased knowledge in this field. With the normal salivary citrate level below 0.1 mM per liter,3' no great significance is to be attached to the effect of the ion on the solubility of calcium salts.…”

Section: The Enamel Apatite Solubility In the Saliva In The Presence mentioning

confidence: 97%

Investigations on the Occurrence and Significance of Citric Acid in the Saliva

Ericsson

1953

J Dent Res

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ITRIC acid has long been recognized as one of the possible chemical causes of b dental erosion.30' 31 Numerous experiments with animals have shown that the citrate-rich fruit juices have an erosive effect on enamel.'9-23' 30, 31 The most obvious mechanism of this effect is an acid dissolution of the salts of the teeth, since orange, grapefruit, and pineapple juices have a reported pH of 3.8 to 4.0.20, 23 In addition, the buffering effect of the citrate ions at a low pH produced by this or other acids may play a part. However, it has also been reported that practically neutral citrate solutions have an erosive effect on the teeth of experimental animals.22 It therefore seems possible that the calciumcombining property of the citrate ions may also have a role in dental erosion by increasing the solubility in the saliva of the calcium salts of the tooth. This latter concept has been supported by the reports of increased solubility of calcium carbonate and calcium phosphate in the presence of citrate.'0' 16, 24The purposes of this investigation have been to study certain features of salivary citrate content and to determine the possible effects of intraoral concentrations of citrate on the solubility of calcium phosphate in saliva. Accordingly, this report is divided into two parts: (1) determination of the variations with time of citrate concentrations in saliva after ingestion of a citric acid-containing food and beverage; and (2) determination of the solubility of the enamel apatite in saliva in the presence of comparable concentrations of citrate. THE INTRAORAL CITRATE RETENTIONMethods.-Samples of unstimulated mixed saliva were collected before and at 2, 5, 10, and 20 minutes after the ingestion of an orange or 100 ml. grapefruit juice. The foods were ingested in portions during a 1-minute period. The first saliva sample had a volume exceeding 1 ml. and was taken at least one hour after the last previous meal. The saliva collections made after the food ingestion were obtained in a standard manner with the subjects resting quietly. One and one-half minutes after completing the ingestion, the subject was asked to swallow and then to let the saliva passively collect in the mouth. After 2.5 minutes the saliva was delivered into a beaker. The 2-minute sample was thus the saliva collected over the 1.5 to 2.5-minute period after the completed ingestion, the 5-minute sample at 4.5 to 5.5 minutes, and so on.

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Section: The Enamel Apatite Solubility In the Saliva In The Presence mentioning

confidence: 97%