2001
DOI: 10.1002/1097-0142(20010215)91:4<833::aid-cncr1071>3.3.co;2-0
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Calcium supplements interact significantly with long‐term diet while suppressing rectal epithelial proliferation of adenoma patients

Abstract: Long-term calcium supplements significantly suppressed REP in adenoma patients, and long-term dietary habits contributed to this effect. Patient diet should be assessed when researchers use REP as a biomarker in calcium chemoprevention studies. Study results indicated that relevant dietary counseling may be useful in addition to calcium supplements in persons at increased risk for colorectal neoplasia.

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“…Cohort and case-control studies do not provide a clear relationship between calcium intake and colon cancer risk, with only a few studies indicating a significant inverse relationship [92,94,95]. Several studies have found gender- specific protection [92], whereas other studies have found calcium intake to have no association with colorectal cancer [92,93,96].…”
Section: Calciummentioning
confidence: 99%
“…Cohort and case-control studies do not provide a clear relationship between calcium intake and colon cancer risk, with only a few studies indicating a significant inverse relationship [92,94,95]. Several studies have found gender- specific protection [92], whereas other studies have found calcium intake to have no association with colorectal cancer [92,93,96].…”
Section: Calciummentioning
confidence: 99%
“…First, some studies suggest it is an anticarcinogen both in diet (105) and as a supplement (106,107). Antineoplastic effects attributed to calcium include inhibition of mucosal hyperproliferation (108,109) or precipitation of bile salts (110,111). Second, more recently, high-dose calcium has been shown to stimulate lactobacilli (112) and interfere with colonization of some pathogens (113,114).…”
Section: Discussionmentioning
confidence: 99%