Calcium signaling in prostate cancer cells: Evidence for multiple receptors and enhanced sensitivity to bombesin/GRP

Wasilenko, William J.; Cooper, Jeffrey B.; Palad, Ann J.; Somers, Kenneth D.; Blackmore, Peter F.; Rhim, Johng S.; Wright, George L.; Schellhammer, Paul F.

doi:10.1002/(sici)1097-0045(19970215)30:3<167::aid-pros4>3.3.co;2-x

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Prostate

1997

DOI: 10.1002/(sici)1097-0045(19970215)30:3<167::aid-pros4>3.3.co;2-x

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Calcium signaling in prostate cancer cells: Evidence for multiple receptors and enhanced sensitivity to bombesin/GRP

William J. Wasilenko¹,

Jeffrey B. Cooper²,

Ann J. Palad³

et al.

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Cited by 3 publications

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The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies

Pennefather

Lau

Mitchelson

et al. 2000

Journal of Autonomic Pharmacology

105

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1. We review literature demonstrating (a) the presence and (b) the actions of substances that mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma of a number of species including man. 2. In all species studied prostatic stroma, but not secretory acini, receives rich noradrenergic innervation. Stimulation of these nerves causes contractions of prostate smooth muscle that are inhibited by guanethidine and by alpha1-adrenoceptor antagonists that probably act at the alpha1L-adrenoceptor. Such actions underlie the clinical use of alpha1-adrenoceptor antagonists in benign prostatic hyperplasia (BPH). 3. Acetylcholinesterase-positive nerves innervate prostatic stroma as well as epithelium. Atropine reduces nerve-mediated contractions of stromal muscle in the rat, guinea-pig and rabbit. M1, M2 and M3 muscarinic receptors have been implicated in eliciting or facilitating contraction in the prostate from guinea-pig, dog and rat, respectively. 4. Adenine nucleotides and nucleosides, nitric oxide (NO), opioids, neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) may act as co-transmitters or modulators in autonomic effector nerves supplying prostate stroma. Adenosine inhibits neurotransmission to the rat prostate, and NO is inhibitory in prostate from human, rat, rabbit, pig and dog. The activity of peptides present in the relatively sparse sensory innervation of the prostate exhibits species variation, but, when effective, calcitonin gene-related peptide is inhibitory while tachykinins are stimulant. The roles of NPY and VIP in modulating stromal contractility remain unclear. 5. Taken together the current literature indicates that, in addition to noradrenaline, other neurotransmitters and neuromodulators may regulate the tone of prostatic smooth muscle. Whether drugs that mimic or modify their actions might be useful in providing symptomatic relief of the urinary symptoms associated with BPH remains to be established.

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The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies

Pennefather

Lau

Mitchelson

et al. 2000

Journal of Autonomic Pharmacology

105

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Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

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SUMMARY1. The human prostate is a compact gland contributing to seminal fluid. With increasing age, most humans will develop benign prostatic hyperplasia, a condition of prostatic enlargement and contractility that leads to occlusion of the urethra. Over many years, investigators have used a variety of animal and cell culture models to elucidate some of the contractile and proliferative mechanisms that may be associated with the development of this condition.2. This review briefly assesses the current state of knowledge of the mechanisms underlying human prostatic contractility and compares it with that of animal and cell culture models. It is not intended as a comprehensive methodological review, nor is it intended to indicate our preferences for either model. Our aim is to correlate findings from animal and cell culture models with the current understanding of human prostate contractility.3. We hope that the present review will increase awareness of the suitability of the current models in developing our understanding of benign prostatic hyperplasia.

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Possible Relationship between Dietary Factors and Pathogenesis of Prostate Cancer

Griffiths

Denis²,

Turkes

et al. 1998

Int J of Urology

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Calcium signaling in prostate cancer cells: Evidence for multiple receptors and enhanced sensitivity to bombesin/GRP

Cited by 3 publications

References 0 publications

The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies

The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies

Current models of human prostate contractility

Possible Relationship between Dietary Factors and Pathogenesis of Prostate Cancer

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