Calcium signaling and genetic rare diseases: An auditory perspective

Richard, E.; Maurice, Tangui; Delprat, Benjamin

doi:10.1016/j.ceca.2023.102702

Cell Calcium

2023

DOI: 10.1016/j.ceca.2023.102702

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Calcium signaling and genetic rare diseases: An auditory perspective

E. Richard

Tangui Maurice

Benjamin Delprat

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Cited by 3 publications

References 165 publications

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Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

Wąsik,

Lisowska,

Słota

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose This study focused on the selected markers of oxidative stress, impact of elevated lead levels on long-term hearing quality. We investigated whether the presence of certain essential minerals might provide protection to the auditory system against the effects of lead (and cadmium) compounds. Methods The research group included 280 male employees of the zinc and lead smelter, which was divided into: L-Pb—low blood lead concentration (PbB) subgroup, H-Pb—high PbB subgroup. Hearing tests were performed using the click evoked otoacoustic emission (CEOAE). Results Zinc protoporphyrin level was significantly higher in the H-Pb subgroup by 68%. Cd concentration was significantly higher in H-Pb by 33%. The Ca concentration was significantly lower in the H-Pb by − 2%. Selected oxidative stress markers concentration were significantly higher in the H-Pb group: malondialdehyde (MDA) by 4%, and lipofuscin (LPS) by 9%. In the CEOAE results showed statistically significant differences between the L-Pb and H-Pb subgroups. Larger negative changes in otoemission amplitude were observed in H-Pb subgroup. All otoemission results showed a statistically significant negative correlation with age, time of work, MDA concentration, and with PbB. Selected CEOAE parameters showed a significant negative correlation with cadmium blood concentration (CdB), and a positive correlation with Ca and Zn. Conclusion Elevated blood lead content in occupational exposure is associated with an increase in MDA and LPS concentration, which negatively correlates with CEOAE parameters. This suggests an important role of oxidative stress in the long-term deterioration of hearing.

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Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

Wąsik,

Lisowska,

Słota

et al. 2024

Eur Arch Otorhinolaryngol

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Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit

Parys,

Bultynck

2023

Cell Calcium

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A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease

Xiang,

Liu,

Chen

et al. 2023

PPL

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Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases. In this paper, the possible mechanism of its action in nervous system-related diseases and treatment are reviewed.

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Calcium signaling and genetic rare diseases: An auditory perspective

Cited by 3 publications

References 165 publications

Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

Click evoked otoacoustic emissions in occupational exposure to lead, concentrations of selected essential elements and markers of oxidative stress

Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit

A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease

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