Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit

Computational insights in cell physiology

“…These events rely on a rather limited number of Ca 2+ transporters and channels allowing for Ca 2+ transfers between the cytoplasm and the other cell compartments, such as the extracellular medium, the endoplasmic reticulum or the mitochondria. Based on a kinetic description of these Ca 2+ -transporting elements arranged in a cell type-and stimulus-specific manner (Berridge et al, 2000;Parys and Bultynck, 2023), computational modeling is much used to help deciphering the molecular mechanisms underlying each specific type of Ca 2+ response (Dupont et al, 2016).…”