Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment

Chovancova, Barbora; Lišková, Veronika; Miklikova, Svetlana; Hudecová, Soňa; Babula, Petr; Penesová, Adela; Sevcikova, Angelika; Durinikova, Erika; Novàkovâ, Marie; Matúšková, Miroslava; Križanová, Oľga

doi:10.1016/j.bcp.2019.113695

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…Furthermore, the combination of Fluorouracil and Curcumin was studied in cancer treatment by Yumeng Wei and colleagues 56 . Barbora Chovancova and colleagues reported that calcium channel blocker Nifedipine inhibits immune escape and colorectal cancer progression 57 . Moreover, in several studies, it has been proved that Nifedipine can promote breast cancer 58 , 59 .…”

Section: Resultsmentioning

confidence: 99%

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

MotieGhader

Tabrizi-Nezhadi

Paskeh

et al. 2022

Sci Rep

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Lung cancer is the most common cancer in men and women. This cancer is divided into two main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Around 85 to 90 percent of lung cancers are NSCLC. Repositioning potent candidate drugs in NSCLC treatment is one of the important topics in cancer studies. Drug repositioning (DR) or drug repurposing is a method for identifying new therapeutic uses of existing drugs. The current study applies a computational drug repositioning method to identify candidate drugs to treat NSCLC patients. To this end, at first, the transcriptomics profile of NSCLC and healthy (control) samples was obtained from the GEO database with the accession number GSE21933. Then, the gene co-expression network was reconstructed for NSCLC samples using the WGCNA, and two significant purple and magenta gene modules were extracted. Next, a list of transcription factor genes that regulate purple and magenta modules' genes was extracted from the TRRUST V2.0 online database, and the TF–TG (transcription factors–target genes) network was drawn. Afterward, a list of drugs targeting TF–TG genes was obtained from the DGIdb V4.0 database, and two drug–gene interaction networks, including drug-TG and drug-TF, were drawn. After analyzing gene co-expression TF–TG, and drug–gene interaction networks, 16 drugs were selected as potent candidates for NSCLC treatment. Out of 16 selected drugs, nine drugs, namely Methotrexate, Olanzapine, Haloperidol, Fluorouracil, Nifedipine, Paclitaxel, Verapamil, Dexamethasone, and Docetaxel, were chosen from the drug-TG sub-network. In addition, nine drugs, including Cisplatin, Daunorubicin, Dexamethasone, Methotrexate, Hydrocortisone, Doxorubicin, Azacitidine, Vorinostat, and Doxorubicin Hydrochloride, were selected from the drug-TF sub-network. Methotrexate and Dexamethasone are common in drug-TG and drug-TF sub-networks. In conclusion, this study proposed 16 drugs as potent candidates for NSCLC treatment through analyzing gene co-expression, TF–TG, and drug–gene interaction networks.

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Section: Resultsmentioning

confidence: 99%

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

MotieGhader

Tabrizi-Nezhadi

Paskeh

et al. 2022

Sci Rep

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“…For instance, an enhanced activity of IP3R1 in prostate cancer promotes cell survival and resistance to hormonal deprivation therapy [167]. More recently, it was reported that IP3R1 plays a different role in MDA-MB-231 breast cancer cells compared to JIMT1 breast cancer cells, DLD1 colorectal and A2780 OC cells [94]. Treatment of these cell lines with the VGCC blocker nifedipine (Table 1) induced an increase of cytosolic Ca 2+ levels in A2780 and DLD1 cells, whereas no changes have been seen in MDA-MB-231 and JIMT1 breast cancer cells.…”

Section: Calcium Channelsmentioning

confidence: 99%

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

Altamura

Greco

Carratù

et al. 2021

Cancers

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Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of platinum resistance, and inadequate alternative therapy. It has been demonstrated that membrane ion channels play important roles in cancer processes, including cell proliferation, apoptosis, motility, and invasion. Here, we review the contribution of ion channels in the development and progression of OC, evaluating their potential in clinical management. Increased expression of voltage-gated and epithelial sodium channels has been detected in OC cells and tissues and shown to be involved in cancer proliferation and invasion. Potassium and calcium channels have been found to play a critical role in the control of cell cycle and in the resistance to apoptosis, promoting tumor growth and recurrence. Overexpression of chloride and transient receptor potential channels was found both in vitro and in vivo, supporting their contribution to OC. Furthermore, ion channels have been shown to influence the sensitivity of OC cells to neoplastic drugs, suggesting a critical role in chemotherapy resistance. The study of ion channels expression and function in OC can improve our understanding of pathophysiology and pave the way for identifying ion channels as potential targets for tumor diagnosis and treatment.

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“…However, in the presence of nifedipine, silencing of the NCX1 did not alter JIMT1 cell proliferation, but significantly decreased the proliferation of MDA-MB-231. This fact suggests differing modulation of the NCX in individual breast cancer types [ 36 ].…”

Section: Ncx1 In Solid Tumorsmentioning

confidence: 99%

Role of Sodium/Calcium Exchangers in Tumors

et al. 2020

Self Cite

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The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted—calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.

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Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment

Cited by 17 publications

References 47 publications

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

Role of Sodium/Calcium Exchangers in Tumors

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