Calcium Retention From Milk-Based Infant Formulas, Whey-Hydrolysate Formula, and Human Milk in Weanling Rhesus Monkeys

Rudloff, Silvia; Lönnerdal, Bo

doi:10.1001/archpedi.1990.02150270110037

Cited by 15 publications

(12 citation statements)

References 22 publications

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“…As for iron absorption, our results are consistent with other in vitro assays [19][20][21] . The high ascorbic acid and citric acid contents of soy-based infant formulas compared to milk-based infant formulas may explain the similar amounts of iron absorbed from both infant formulas 19 .…”

Section: Discussionsupporting

confidence: 91%

“…The negative effects were attributed to phytate 10 and to the types of peptides released during protein digestion 11,14,16 . However, other studies have shown no negative effect on iron [17][18][19] or calcium 20,21 absorption when comparing soybased infant formula to milk-based infant formula. In fact, some studies have reported that the bioavailability of calcium from soy-based infant formula is higher with than from milk-based infant formula 19,22,23 .…”

Section: Introductionmentioning

confidence: 98%

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Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

et al. 2017

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ObjectiveThis study aimed to compare the intestinal absorption of iron and calcium between soy-based and cow's milk-based infant formulas in weanling rats. MethodsTwenty male Wistar rats, twenty-one days old on the first day of weaning, were used in this experiment, divided in two Groups, one Group was fed soy protein-based infant formula the other, cow's milk protein-based infant formula. During the study period (ten consecutive days) the animals received food and water ad libitum. Hematocrit and hemoglobin were evaluated on the first, fifth, and tenth days by the Wintrobe and cyanomethemoglobin methods. Feces and urine were collected, beginning on the fifth day, for three consecutive days. On the tenth day, hepatic iron content was also analyzed. Hepatic iron as well as fecal and urinary iron and calcium analyses were performed using an atomic absorption spectrophotometer. At thirty-one days of age, the animals were anesthetized with ketamine and xylazine and sacrificed by exsanguination via the vena cava.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

et al. 2017

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“…As has been shown for calcium, [11][12][13][14][15][16][17][18][19][20][21][22] the distribution of the added radiolabel 65Zn among com¬ ponents in infant formulas is similar to the zinc already present (native zinc).23 In addition, it has been shown that extrinsic labeling gives identical results to intrinsic label¬ ing for both calcium22 and zinc.24 This strongly supports the use of an extrinsic label.…”

Section: Resultsmentioning

confidence: 74%

Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Rudloff¹

1992

Arch Pediatr Adolesc Med

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“…Also, monkey infants can be raised in primate nurseries where the amount and timing of iron in the diet can be precisely controlled through use of infant formulas. Infant monkeys have been used extensively as models for human infants to study absorption, growth and development with formulas of different nutritional content [11,13,35,51,58,41,42,43,33,40,54,57].…”

Section: Introductionmentioning

confidence: 99%

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Golub

Hogrefe

Germann

et al. 2006

Neurotoxicology and Teratology

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Human studies have shown that iron deficiency and iron deficiency anemia in infants are associated with behavioral impairment, but the periods of brain development most susceptible to iron deficiency have not been established. In the present study, rhesus monkeys were deprived of iron by dietary iron restriction during prenatal (n = 14, 10 μg Fe/g diet) or early postnatal (n = 12, 1.5 mg Fe/L formula) brain development and compared to controls (n = 12, 100 μg Fe/g diet, 12 mg Fe/L formula) in behavioral evaluations conducted during the first four months of life in the nonhuman primate nursery. Iron deficiency anemia was detected in the pregnant dams in the third trimester and compromised iron status was seen in the prenatally iron-deprived infants at birth, but no iron deficiency was seen in either the prenatally or postnatally iron-deprived infants during the period of behavioral evaluation. Neither prenatal nor postnatal iron deprivation led to significant delays in growth, or gross or fine motor development. Prenatally deprived infants demonstrated a 20% reduced spontaneous activity level, lower inhibitory response to novel environments, and more changes from one behavior to another in weekly observation sessions. Postnatally deprived infants demonstrated poorer performance of an object concept task, and greater emotionality relative to controls. This study indicates that different syndromes of behavioral effects are associated with prenatal and postnatal iron deprivation in rhesus monkey infants and that these effects can occur in the absence of concurrent iron deficiency as reflected in hematological measures.

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Calcium Retention From Milk-Based Infant Formulas, Whey-Hydrolysate Formula, and Human Milk in Weanling Rhesus Monkeys

Cited by 15 publications

References 22 publications

Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

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