Calcium, potassium, magnesium and amylase disturbances in acute pancreatitis

Edmondson, Hugh A.; Berne, Clarence J.; Homann, Ralph E.; Wertman, Maxine

doi:10.1016/0002-9343(52)90166-6

Cited by 138 publications

(18 citation statements)

References 19 publications

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“…These results were accounted for by growth involving the para-aortic glands in close relation to the pancreas. Raised serum lipase values have been reported in advanced metastatic cancer of the liver, when the primary tumour was in the bronchus (Edmondson, Berne, Homann, and Wertman, 1952) and in the colon (Johnson and Bockus, 1940). Neither of our patients had detectable secondary deposits in the liver at the time of the test.…”

Section: Discussionmentioning

confidence: 99%

Serum Amylase and Serum Lipase Levels in Man after Administration of Secretin and Pancreozymin

Burton¹,

Hammond²,

Harper³

et al. 1960

Gut

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A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic disease, in biliary and hepatic diseases have been analysed and compared with the results of duodenal intubation and an oral glucose tolerance test. A combined evocative test and oral glucose tolerance test provide evidence of pancreatic dysfunction in the majority of cases of cancer of the pancreas and chronic pancreatitis. The conditions of the test are described and the pathological lesions in which false positive evocative tests may be found are indicated.The simple evocative test provides the earliest biochemical evidence of pancreatic disease in some patients with cancer of the pancreas and chronic pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Serum Amylase and Serum Lipase Levels in Man after Administration of Secretin and Pancreozymin

Burton¹,

Hammond²,

Harper³

et al. 1960

Gut

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“…Edmondson et al (1952) and Roberts et al (1950) have drawn attention to the dangerous degree of hypochloraemia and hypokalaemia which may occur in pancreatic necrosis; and a factor which the former authors show to have been hitherto neglected is the binding of calcium when fat necrosis is extensive, indicating' that intravenous injections of calcium gluconate should be given in severe cases.…”

Section: Treatmnwtmentioning

confidence: 99%

Studies on Pancreatitis

Saint¹,

Weiden²

1953

BMJ

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“…(Submitted for publication December 12, 1956; accepted April 11, 1957) Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion.…”

mentioning

confidence: 99%

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Barnes¹,

Gordon²,

Cope³

1957

J. Clin. Invest.

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Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1-11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion. This mineral is located almost exclusively in the cells or in the skeleton, and calculations based on a standard reference (16) 114-198. protoplasm, because of the accumulated information concerning its composition, and because of its availability at almost any operation.Definition of the intra-and extracellular spaces: A biochemical dissection. In the absence of an infallible technique for distinguishing between the intracellular phase and extracellular phase we have accepted the chloride space as an approximation of the extracellular space. It is well recognized that in diseased states where chloride ions may penetrate into the muscle fiber cell, the extracellular space -will be falsely enlarged. However, the chloride space still remains a most reasonable and practical means of correcting for the extracellular components to permit calculation by difference of the intracellular components. The evidence for the extracellular location of the chloride ion and for the proportionality of its total mass to the extracellular space has been recently reviewed (19).Bases of reference in expressing the concentrations of the muscle components. In tissue analyses advantages exist in expressing the results in terms of more than one reference base. Changes in the concentrations of the components in relation to one base might not appear in relating the concentrations to another due to a concomitant shift of the second base. Other considerations in the selection of a reference base are the effects of analytical variations in its determination which would cause fluctuations devoid of any biological significance and the natural variation of a reference base which should be as restricted as possible to minimize the confusion this would introduce into the interpretations. These independent characteristics may be assessed by statistical techniques outlined below.The reference base of intracellular water introduced by Hastings and Eichelberger (20) has been justified by water being the most plentiful constituent of tissues and by the success achieved in unfolding the properties of blood as a physiochemical system approximating a simple aqueous solution. More recently the use of non-collagen nitrogen (NCN), proposed by Lilienthal, Zierler, Folk, Buka, and Riley (21), as a reference base has the advantage of relating the intracellular components to a standard that is independent of any assumptions that the use of the chloride space entails in the calculation of the intracellular water. The non-collagen nitrogen, which is defined as...

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Calcium, potassium, magnesium and amylase disturbances in acute pancreatitis

Cited by 138 publications

References 19 publications

Serum Amylase and Serum Lipase Levels in Man after Administration of Secretin and Pancreozymin

Serum Amylase and Serum Lipase Levels in Man after Administration of Secretin and Pancreozymin

Studies on Pancreatitis

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

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