Calcium phosphate-quercetin nanocomposite (CPQN): A multi-functional nanoparticle having pH indicating, highly fluorescent and anti-oxidant properties

Patra, Mousumi; Mukherjee, Riya; Banik, Milon; Dutta, Dipak; Begum, Naznin Ara; Basu, Tarakdas

doi:10.1016/j.colsurfb.2017.03.018

Cited by 34 publications

(20 citation statements)

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“…Some complex ionic complexes, such as glucan–quercetin conjugate [75], calcium phosphate–quercetin nanocomplex (CPQN) [76], and quercetin–germanium nanoparticles [77], have higher antioxidant activity than free quercetin. Similar to quercetin complexes with metal ions, complexes with complex ions have been applied in medicine and other pharmaceutical fields.…”

Section: Chemical Studies On the Antioxidant Activity Of Quercetinmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. In recent years, antioxidant activities of quercetin have been studied extensively, including its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) caused by environmental and toxicological factors. Chemical studies on quercetin have mainly focused on the antioxidant activity of its metal ion complexes and complex ions. In this review, we highlight the recent advances in the antioxidant activities, chemical research, and medicinal application of quercetin.

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Section: Chemical Studies On the Antioxidant Activity Of Quercetinmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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“…Recently, new quercetin preparations have appeared, including quercetin-loaded gel, quercetin-loaded mucoadhesive nanoemulsion, quercetin-loaded nanoparticles, and quercetin-loaded polymeric micelle, which may provide new drug formulations for research and development ( Figure 3) [31]. Moreover, quercetin bioavailability has also been improved by structural modification with glucoside-sulfate conjugates and the preparation of some complex ionic complexes, such as quercetin-germanium nanoparticles, calcium phosphate-quercetin nanocomplex (CPQN), and glucan-quercetin conjugate that showed higher antioxidant activity than free quercetin [99]. Quercetin also exhibits excellent antioxidant activity and scavenging capacity when combined with metal ions, such as cadmium, vanadium, calcium, magnesium, copper, cobalt, iron, and ruthenium [31].…”

Section: Metabolism and Excretion Of Quercetinmentioning

confidence: 99%

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Batiha

Beshbishy

Ikram

et al. 2020

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Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin.

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“…Moreover, interaction of quercetin with CPNP, through Ca2+ ions, enhanced its intrinsic fluorescence by more than 5000 times and thereby CPQN might be used in biological field as a potent fluorophore, having no cytotoxicity because of the high biocompatibility of the two main components of the NPs -quercetin and calcium phosphate ( Figure 9). The nanocomposite had potential anti-oxidant property, because complexation with metal ions decreased the oxidation potential of flavonoids, for which mortality of mouse neuroblastoma cell N2A, by H 2 O 2 -induced oxidative stress, was found to be lowered by the pre-treatment of the cells with CPQN [131].…”

Section: Calcium Phosphate Nanoparticlementioning

confidence: 99%

“…Cells treated with 5 µg/mL CPQN for 1 h (A), for 24 h (B), and with 5 µg/mL bulk quercetin for 24 h (C); 1, 2, and 3 represent blue-filtered, bright field, and overlay images, respectively. Adapted with permission from Ref [131]…”

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confidence: 99%

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

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Calcium phosphate-quercetin nanocomposite (CPQN): A multi-functional nanoparticle having pH indicating, highly fluorescent and anti-oxidant properties

Cited by 34 publications

References 54 publications

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

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