Calcium phosphate phases integrated in silica/collagen nanocomposite xerogels enhance the bioactivity and ultimately manipulate the osteoblast/osteoclast ratio in a human co-culture model

Heinemann, Sascha; Heinemann, Christiane; Wenisch, Sabine; Alt, Volker; Worch, H.; Hanke, Thomas

doi:10.1016/j.actbio.2012.10.010

Cited by 82 publications

(89 citation statements)

References 58 publications

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“…Moreover, a comparatively higher density of small multinuclear osteoclasts was observed to be evenly distributed in the monocultivation of human monocytes (hMcs) on triphasic xerogels in comparison to that on biphasic xerogels. Thus, highly bioactive materials favored osteoclasts over the osteoblasts, whereas low bioactive materials favored osteoblasts over osteoclasts, when both cell lineages were combined in co-culture [52] . The high level of bioactivity of the triphasic xerogels reduced the calcium concentration in the medium, which inhibited the proliferation and differentiation of osteoblasts.…”

Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 97%

“…Silica-collagen nanohybrids have been observed to act as skeletal structure in nature (e.g., marine basal spicules), which were successfully reproduced in vitro by applying sol-gel technique [52] . In fact, Brought to you by | Universitaet Giessen Authenticated Download Date | 5/25/15 5:59 PM sol-gel is the most used technique to fabricate silica-collagen hydrogel and xerogel composites.…”

Section: Sol-gel/polycondensation-based Materialsmentioning

confidence: 99%

“…Heinemann et al [52] used silica-collagen xerogels for the investigation of the influence of embedded HA-like CPPs on physiological as well as biological properties. Silica-collagen xerogels were developed by sol-gel technique.…”

Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 99%

“…Therefore, the bioactivity of silica-collagen xerogels can be controlled to make the optimum balance of osteoblasts to osteoclasts, which is essential for healthy bone formation. Moreover, it was revealed by Heinemann et al [52] that the differentiation of monocytes to osteoclasts was higher for the biphasic xerogels compared to triphasic xerogels, which was evaluated by the detection of tartrate resistant acid phosphatase (TRAP) 5b activity in the monoculture as well as in the co-culture with hBMSCs/HOS.…”

Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 99%

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Collagen/silica nanocomposites and hybrids for bone tissue engineering

Sarker

Lyer

Arkudas³

et al. 2013

Nanotechnology Reviews

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Collagen is increasingly attracting attention for bone tissue engineering applications. However, due to its low mechanical properties, applications including mechanical loads or requiring structural integrity are limited. To tackle this handicap, collagen can be combined with (nanoscale) silica in a variety of composite materials that are attractive for bone tissue engineering. Considering research carried out in the past 15 years, this article reviews the literature discussing the development of silica/collagen composites that have been synthesized by adding silica from different sources as inorganic bioactive material to collagen as organic matrix. Different routes for the fabrication of collagen/silica composites are presented, focusing on nanocomposites. In vitro cell bioactivity studies demonstrated the osteogenic and, in some cases, angiogenic potential of the composites. Relevant in vivo studies discussing integration of the materials in bone tissue are discussed. Due to the understanding of possible interaction between silicon species and collagen, the effect of different silica precursors on the collagen self-assembly process is also discussed. On the basis of literature results and as discussed in this review, collagen/ silica nanocomposites and hybrids represent attractive biomaterials for bone regeneration applications.

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Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 97%

Section: Sol-gel/polycondensation-based Materialsmentioning

confidence: 99%

Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 99%

Section: Silica Precursors Chemical Structure Referencesmentioning

confidence: 99%

See 2 more Smart Citations

Collagen/silica nanocomposites and hybrids for bone tissue engineering

Sarker

Lyer

Arkudas³

et al. 2013

Nanotechnology Reviews

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“…The remodeling procedure is regulated by few growth factors, hormones and inorganic ions such as Calcium (Ca) (Heinemann et al, 2013;Julien et al, 2007;Liu, 2003;Saltman and Strause, 1993), Phosphorous(p) (Heinemann et al, 2013;Julien et al, 2007), Silicon (Si) (Liu, 2003), Strontium(Sr) (Liu, 2003), Zinc(Zn) (Liu, 2003;Saltman and Strause, 1993), Boron(B), Vanadium(V), Cobalt (Co), Magnesium(Mg) (Cepelak et al, 2013), Magneese (Mn, Copper(Cu) (Liu, 2003;Saltman and Strause, 1993). Inorganic ions dissolution plays a very important role in the process of bone healing (Mouriño et al, 2012).…”

Section: Role Of Inorganic Ions In Bone Metabolismmentioning

confidence: 99%

Periodontal Bone Substitutes Application Techniques and Cost Evaluation: A Review

Syed¹,

Sahar²,

Aversa³

et al. 2016

American Journal of Engineering and Applied Sciences

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Bioactive Materials have been used since decades but the researches on these materials are still continuing in phase. This material got extra ordinary attention by the scientist and researchers. Bioactive material has ability to bind itself chemically with natural bone tissues. Bioactive materials bring revolution in the field of bone repair and implantology. Bioactive materials have also ability to effect on gene activation of osteoblastic cells that enhance proliferation, resulting rapid bone formation. At last the techniques through which bioactive materials are used to deposits on the implant, to create bond between implants and the bone. Cost evaluation is the very essential part that classifies the use of material commercially.

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Multiphase Biomineralization: Enigmatic Invasive Siliceous Diatoms Produce Crystalline Calcite

Ehrlich

Motylenko

Sundareshwar

et al. 2016

Adv Funct Materials

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Diatoms are considered unicellular eukaryotic organisms exclusively depositing biogenic silica. Heretofore there has been no report of calcifi cation by these algae. Here it is shown that calcium carbonate within the stalks of Didymosphenia geminata , a nuisance species that has prolifi cally colonized streams and rivers globally, is biogenic in origin and occurs as a network of calcite nanofi bers. The nanofi brous framework in the mineralized polysaccharide matrix imparts mechanical support to the stalks, providing stability in variable fl ow conditions. The results demonstrate that D. geminata possesses cellular and periplasmic carbonic-anhydrases that contribute to carbon fi xation and biomineralization, respectively. The activity of external carbonic-anhydrase was more than 50% of the total activity, which points to its role in anchoring this bioeroding diatom on hard surfaces. The fi rst evidence of multiphase biomineralization by diatoms that deposit both biogenic silica and crystalline biogenic calcite which are imparting distinct functional advantage to the organism is provided.

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Calcium phosphate phases integrated in silica/collagen nanocomposite xerogels enhance the bioactivity and ultimately manipulate the osteoblast/osteoclast ratio in a human co-culture model

Cited by 82 publications

References 58 publications

Collagen/silica nanocomposites and hybrids for bone tissue engineering

Collagen/silica nanocomposites and hybrids for bone tissue engineering

Periodontal Bone Substitutes Application Techniques and Cost Evaluation: A Review

Multiphase Biomineralization: Enigmatic Invasive Siliceous Diatoms Produce Crystalline Calcite

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