Calcium phosphate nanoparticles as versatile carrier for small and large molecules across cell membranes

Sokolova, Viktoriya; Rotan, Olga; Klesing, Jan; Nalbant, Perihan; Buer, Jan; Knuschke, Torben; Westendorf, Astrid M.; Epple, Matthias

doi:10.1007/s11051-012-0910-9

Cited by 44 publications

(39 citation statements)

References 28 publications

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“…Usually, nanoparticles alone cannot penetrate the cell membrane, but they can enter the cells in membrane-bound vesicles by endocytosis [42,43]. Endocytosis pathways generally include clathrin-mediated endocytosis, caveolin-mediated endocytosis, clathrin-or caveolin-independent endocytosis, and macropinocytosis [44,45].…”

Section: Discussionmentioning

confidence: 99%

Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery

Wang

You

et al. 2016

Journal of Controlled Release

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Section: Discussionmentioning

confidence: 99%

Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery

Wang

You

et al. 2016

Journal of Controlled Release

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“…A number of studies have been devoted to the packaging of DNA, RNA, and oligonucleotides molecules in calcium phosphate nanoparticles [77]. The advantage of using calcium phosphate particles is that the size of these carriers can be adjusted on the ten-to-hundred nanometer scale which is important in cell transfection [78]. Furthermore, these carriers exert a protective role on the embedded material against the cellular environment, and allow for specific targeting functionalization of the calcium phosphate surface [79].…”

Section: Microparticles As Carriers Of Enzymesmentioning

confidence: 99%

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Parakhonskiy

Yashchenok

Konrad

et al. 2014

Advances in Colloid and Interface Science

108

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Colloidal particles play an important role in various areas of material and pharmaceutical sciences, biotechnology, and biomedicine. In this overview we describe micro-and nano-particles used for the preparation of polyelectrolyte multilayer capsules and as drug delivery vehicles. An essential feature of polyelectrolyte multilayer capsule preparations is the ability to adsorb polymeric layers onto colloidal particles or templates followed by dissolution of these templates. The choice of the template is determined by various physico-chemical conditions: solvent needed for dissolution, porosity, aggregation tendency, as well as release of materials from capsules. Historically, the first templates were based on melamine formaldehyde, later evolving towards more elaborate materials such as silica and calcium carbonate. Their advantages and disadvantages are discussed here in comparison to non-particulate templates such as red blood cells. Further steps in this area include development of anisotropic particles, which themselves can serve as delivery carriers. We provide insights into application of particles as drug delivery carriers in comparison to microcapsules templated on them.

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“…[82,[113][114][115][116][117][118][119][120] Eukaryotische, nicht phagozytierende Zellen nehmen SilberNanopartikel durch Endozytose und Makropinozytose auf. [112,121] Dabei konnten die Nanopartikel durch die Kombination von Focussed Ion Beam (FIB), Rasterelektronenmikroskopie und energiedispersiver Rçntgenspektroskopie direkt in der Zelle sichtbar gemacht werden.…”

Section: Biologische Wirkung Von Silberunclassified

“…[112,121] Dabei konnten die Nanopartikel durch die Kombination von Focussed Ion Beam (FIB), Rasterelektronenmikroskopie und energiedispersiver Rçntgenspektroskopie direkt in der Zelle sichtbar gemacht werden. [121] Alternative Methoden sind die Verfolgung fluoreszierender Nanopartikel durch konfokale Laserscanningmikroskopie [120,122] und Fluoreszenzmikroskopie, [123] oberflächenverstärkte Raman-Spektroskopie (SERS) [124] und Transmissionselektronenmikroskopie. [96] Die Silber-Nanopartikel werden dabei -wie alle Nanopartikel -in biologischen Medien schnell von einer Hülle ("Korona") aus Proteinen umhüllt, [125][126][127][128][129][130][131] was die Interaktion mit Zellen beeinflusst.…”

Section: Biologische Wirkung Von Silberunclassified

Silber als antibakterielles Agens: Ion, Nanopartikel, Metall

Chernousova

Epple

2012

Angewandte Chemie

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Die antibakterielle Wirkung von Silber wird in zahlreichen Haushalts‐ und Medizinprodukten genutzt. Dabei kommen außer Beschichtungen aus metallischem Silber auch Silbersalze und zunehmend auch Silber‐Nanopartikel zum Einsatz. Der Stand der Forschung zur Wirkung von Silber auf Bakterien, Zellen und höhere Organismen wird zusammengefasst. Es zeigt sich, dass das therapeutische Fenster für Silber kleiner ist, als oft angenommen wird. Gleichwohl sind die Risiken durch die Verwendung von Silber für Menschen und Umwelt als begrenzt einzuschätzen.

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Calcium phosphate nanoparticles as versatile carrier for small and large molecules across cell membranes

Cited by 44 publications

References 28 publications

Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery

Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Silber als antibakterielles Agens: Ion, Nanopartikel, Metall

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