Calcium phosphate composite cements based on simple mixture of brushite and apatite phases

Egorov, A. A.; Fedotov, A. Yu.; Pereloma, I. S.; Teterina, A. Yu.; Сергеева, Н. С.; Свиридова, И. К.; Кирсанова, В. А.; Ахмедова, С. А.; Нестерова, А. В.; Решетов, И. В.; Баринов, С. М.; Komlev, V. S.

doi:10.1088/1757-899x/347/1/012039

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…If the bone cement is highly porous, then its ability to integrate with the surrounding bone tissue is better. Also, if the pores are fine interconnected, cells adhesion on the surface increase 13 . Therefore, to achieve and improve the macroporosity and pores interconnectivity in the CPCs, different types of porogen agents were investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Also, if the pores are fine interconnected, cells adhesion on the surface increase. 13 Therefore, to achieve and improve the macroporosity and pores interconnectivity in the CPCs, different types of porogen agents were investigated. Solid porogen agents such as naphthalene, sodium bicarbonate, sucrose, sodium chloride, and mannitol, polymeric porogens such as polymeric sponges, poly lactic-co-glycolic acid microspheres, polyurethane foams, polyethylene glycol, polycaprolactone and polyvinyl alcohol sponges, and liquid foaming agents such as polysorbate (tween-80), pluronic F-127, and gas-generating compound, that is, hydrogen peroxide are reported in the literature to get better pores size distribution in CP-based bioceramics.…”

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confidence: 99%

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Fabrication of macroporous apatite bone cements for non‐load bearing orthopedic applications

et al. 2022

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Calcium deficient hydroxyapatite (CDHA)‐based apatite forming bone cements are well known for their bioactivity and bioresorbability. The formulation of CDHA‐based cements with improved macroporosity, injectability, and resorbability has been investigated. The solid phase consists of nanocrystalline hydroxyapatite (HA) and tricalcium phosphate (β‐TCP). The liquid phase is diluted acetic acid with disodium hydrogen phosphate as binding accelerator along with gelatin and chitosan to improve the injectability. A porogen agent either mannitol (as solid porogen) or polysorbate (as liquid porogen) is also used to improve the porosity. All combined in fine‐tuned composition results in optimal bone cements. The cement sets within the clinically preferred setting time (≤20 min) and injectability (>70%) and also stable at physiological pH (i.e., ~7.3–7.4). The XRD and FT‐IR analysis confirmed the formation of CDHA phase on day 7 when the after‐set cement immersed under phosphate buffer solution (PBS) at physiological conditions. The cements were found to have acceptable compressive strength for trabecular bone substitute. The cements were macroporous in nature with average pore size between 50 and 150 μm and were interconnected as confirmed by SEM, micro‐CT and MIP analysis. The prepared cements are degradable up to 22% and 19% in simulated body fluid and PBS respectively within 10 weeks of immersion at physiological conditions. The cements exhibit higher viability (%) (>110%) with L929 and MG63 cells compared to the control after 3 days of incubation. They also show increased proliferation, well spreading and extended filopodia with MG63 cells. Overall, the developed apatite forming bone cements seems to be suitable for low or non‐load bearing orthopedic applications.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Fabrication of macroporous apatite bone cements for non‐load bearing orthopedic applications

et al. 2022

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“…Obtaining it involves mixing one or more powders with a liquid [19]. Reported systems include mixtures of calcium orthophosphate and aqueous solutions such as phosphatebuffered saline (PBS) [20], orthophosphoric acid [21,22], and citric acid [23].…”

Section: Introductionmentioning

confidence: 99%

“…The main disadvantages of brushite-based cements are the handling time which is usually too short to be used efficiently [24] and the temperatures reached by the exothermic cure reaction [25,26]. Thus, these cements need additives to adjust their properties for specific applications [22,26]. Rödel et al [27] studied PEG hydrogels in cement samples showing that there was no inhibition of brushite phase formation.…”

Section: Introductionmentioning

confidence: 99%

“…Laniesse et al [30] evaluated the manipulation and curing time of wollastonite (CaSiO 3 ) based brushite cements. Mosselmans et al [31] and Egorov et al [22] evaluated the cure and structure of brushite cement obtained from the phosphoric acid-wollastonite system. In addition, the use of polyethylene glycol (PEG) as an additive in bone cements has been reported [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of brushite/polyethylene glycol cement for filler in bone tissue injuries

et al. 2021

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The objective of this work was to produce brushite cement for orthopedic applications, based on the system wollastonite/phosphoric acid with the incorporation of polyethylene glycol (PEG) as a setting and processing additive. Brushite/PEG cement was obtained by the dissolution-precipitation method and its physicochemical properties were characterized by X-ray diffraction, compressive strength, porosimetry, and biological behavior (cell adhesion and bioactivity tests). The results indicated the formation of brushite cement with 21.4 MPa of compressive strength and 30% porosity, similar to human trabecular bone. The surface was shown to be adequate for cell adhesion and growth and bioactive with the formation of apatite layers. The incorporation of PEG improved working conditions without causing undesirable changes in the physicochemical properties and biological behavior of developed cement, thus promising for the repair of bone tissue injuries.

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Injectable macroporous naturally‐derived apatite bone cement as a potential trabecular bone substitute

Dewangan,

Sampath Kumar,

Doble

et al. 2024

J Biomed Mater Res

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In this study, we have formulated a novel apatite bone cements derived from natural sources (i.e. eggshell and fishbone) with improved qualities that is, porosity, resorbability, biological activity, and so forth. The naturally‐derived apatite bone cement (i.e. FBDEAp) was prepared by mixing hydroxyapatite (synthesized from fishbone) and tricalcium phosphate (synthesized from eggshell) as a solid phase with a liquid phase (a dilute acidic blend of cement binding accelerator and biopolymers like gelatin and chitosan) with polysorbate (as liquid porogen) to get a desired bone cement paste. The prepared cement paste sets within the clinically acceptable setting time (≤20 min), easily injectable (>85%) through hands and exhibits physiological pH stability (7.3–7.4). The pure apatite phased bone cement was confirmed by x‐ray diffraction and Fourier transform infrared spectroscopy analyses. The FBDEAp bone cement possesses acceptable compressive strength (i.e. 5–7 MPa) within trabecular bone range and is resorbable up to 28% in simulated body fluid solution within 12 weeks of incubation at physiological conditions. The FBDEAp is macroporous in nature (average pore size ~50–400 μm) with interconnected pores verified by SEM and micro‐CT analyses. The FBDEAp showed significantly increased MG63 cell viability (>125% after 72 h), cell adhesion, proliferation, and key osteogenic genes expression levels (up to 5–13 folds) compared to the synthetically derived, synthetic and eggshell derived as well as synthetic and fishbone derived bone cements. Thus, we strongly believe that our prepared FBDEAp bone cement can be used as potential trabecular bone substitute in orthopedics.

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Calcium phosphate composite cements based on simple mixture of brushite and apatite phases

Cited by 8 publications

References 11 publications

Fabrication of macroporous apatite bone cements for non‐load bearing orthopedic applications

Fabrication of macroporous apatite bone cements for non‐load bearing orthopedic applications

Synthesis of brushite/polyethylene glycol cement for filler in bone tissue injuries

Injectable macroporous naturally‐derived apatite bone cement as a potential trabecular bone substitute

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