Calcium phosphate ceramics in drug delivery

Bose, Susmita; Tarafder, Solaiman; Edgington, Joe; Bandyopadhyay, Amit

doi:10.1007/s11837-011-0065-7

Cited by 34 publications

(16 citation statements)

References 59 publications

(50 reference statements)

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“…[29] Properties such as in vivo osteoconductivity, bioactivity, and resorbability of this group of materials are dependent upon their Ca/P atomic ratio, crystallographic structure, and porosity (or surface area) and have been reviewed elsewhere. [30, 31] …”

Section: Scaffold Fabrication Routesmentioning

confidence: 99%

Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair

Saiz

Rahaman

et al. 2013

Adv Funct Materials

202

142

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The need for implants to repair large bone defects is driving the development of porous synthetic scaffolds with the requisite mechanical strength and toughness in vivo. Recent developments in the use of design principles and novel fabrication technologies are paving the way to create synthetic scaffolds with promising potential for reconstituting bone in load-bearing sites. This article reviews the state of the art in the design and fabrication of bioactive glass and ceramic scaffolds that have improved mechanical properties for structural bone repair. Scaffolds with anisotropic and periodic structures can be prepared with compressive strengths comparable to human cortical bone (100–150 MPa), while scaffolds with an isotropic structure typically have strengths in the range of trabecular bone (2–12 MPa). However, the mechanical response of bioactive glass and ceramic scaffolds in multiple loading modes such as flexure and torsion — as well as their mechanical reliability, fracture toughness, and fatigue resistance — has received little attention. Inspired by the designs of natural materials such as cortical bone and nacre, glass-ceramic and inorganic/polymer composite scaffolds created with extrinsic toughening mechanisms are showing potential for both high strength and mechanical reliability. Future research should include improved designs that provide strong scaffolds with microstructures conducive to bone ingrowth, and evaluation of these scaffolds in large animal models for eventual translation into clinical applications.

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Section: Scaffold Fabrication Routesmentioning

confidence: 99%

Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair

Saiz

Rahaman

et al. 2013

Adv Funct Materials

202

142

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“…In contrast to PMMA cements, CPC formation takes place by hydrolytic and redox reactions instead of a polymerization [200]. After hardening, the kinetic of CPC degradation and resorption is mostly dictated by the Ca/P ratio and consequently it becomes possible to control the rate of bone formation by changing this ratio [199].…”

Section: Intraosseous Forming Implantsmentioning

confidence: 99%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent.Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain.This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment. KeywordsInduced hyperthermia, chemotherapy, drug delivery systems, in situ forming implants, iron oxide nanoparticles, bone metastases, cementoplasty, vertebroplasty 3

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“…To be used as a drug carrier, the potential substance must have the ability to incorporate a drug either physically or chemically, retain the drug until it reaches the specific target site, be gradually degraded, and deliver the drug in a controlled manner over time [5]. All these criteria are well met by calcium phosphates (CaPs), and as a result, these materials are promising candidates for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2012

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Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

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Calcium phosphate ceramics in drug delivery

Cited by 34 publications

References 59 publications

Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair

Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

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