Calcium phosphate-based ceramic and composite materials for medicine

Баринов, С. М.

doi:10.1070/rc2010v079n01abeh004098

Cited by 142 publications

(39 citation statements)

References 73 publications

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“…Although the bending strength values reported for CPCs are typically in the range of 5-15 MPa (Martin & Brown 1995;Ginebra et al 2001), close to that of trabecular bone (estimated between 10 and 20 MPa) (Barinov 2010), their strain to failure is much lower . The brittleness of CPCs has recently been highlighted in a report on their strain-to-crack-initiation, which amounted to a mere 0.2% in compression (Ajaxon et al 2017).…”

Section: Introductionmentioning

confidence: 82%

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

Gallinetti

Mestres

Canal

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to nonload-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiberreinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line. Graphical Abstract (for review) Highlights HIGHLIGHTS• Calcium phosphate cements were reinforced with chitosan fibers and soluble chitosan• The chemical affinity of fibers and matrix improved interfacial adhesion• Mechanical reinforcement was achieved thanks to a good fiber-matrix adhesion• Fiber-reinforced cements were significantly tougher than non-reinforced analogues • The modified cement matrix supported osteoblast proliferation 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 -2 - AbstractCalcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line.

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Section: Introductionmentioning

confidence: 82%

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

Gallinetti

Mestres

Canal

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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“…Наблюдается кристаллизация вторичных стержневид-ных кристаллов ГАП в порах и промежутках между агло-мератами. По данным [13] такая кристаллизация ведет к упрочнению керамики.…”

Section: результаты и обсуждениеunclassified

Development of a biomaterial based on HAP/TiOy nanocomposite with different stoichiometry

Rempel¹,

Валеева²,

Богданова³

et al. 2017

LoM

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At present, composite materials based on bioactive hydroxyappatite (HAP) are intensively developed. To achieve better mechanical properties, different additives are used, for example, titanium, zirconium, etc. In the present study, a dispersionhardened composite material based on nanocrystalline HAP and nanocrystalline titanium monoxide (TiO y , y = 0.92, 1.23) is prepared by low temperature annealing in vacuum. As an additive, titanium monoxide with different mass ratios and stoichiometries (10 or 20 mass % of substoichiometric TiO 0.92 or superstoichiometric TiO 1.23 ) is used. For the preparation of nanocrystalline powders and mixing of initial components, a planetary ball mill was used. According to scanning electron microscopy (SEM) data, using of the ball milling for mechanical mixing of nanopartilces allows one to prepare denser material with a particle shape, which facilitates cold pressing and sintering. It has been established that introducing of the TiO y additive leads to a reduction of the starting temperature of the composite material hardening by 200 to 250°С. The phase composition and properties of the end product (microhardness, density) depend on the stoichiometry and on the amount of additives. For the content of 20 mass % of substoichiometric TiO 0.92 phases Ti 4.5 O 5 and Ti 6 O 11 are found by means of XRD studies. The phase Ti 4.5 O 5 is an ordered phase and is more stable as compared to other phases of Ti-O system., while the phase Ti 6 O 11 has easy slip crystallographic planes. Presence of such two phases positively influences on mechanical properties of the composite. According to SEM, BET and microhardness data, the composites prepared are nanodispersed ones and show an increased density and microhardness as compared to HAP without additives. Ключевые слова: гидроксиапатит, монооксид титана, размол, отжиг, микротвердость.

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“…The bone system of a living organism is formed and maintained by complex biochemical reactions (Barinov 2010; Dorozhkin 2010). The main elements of these reactions are Ca, P, O, H, Na, and Mg.…”

Section: Introductionmentioning

confidence: 99%

The effect of sodium and magnesium ions on the properties of calcium–phosphate biomaterials

2019

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A calcium–phosphate system was obtained by sol–gel method from 0.4 M solutions based on ethyl alcohol, tetraethoxysilane, phosphoric acid, calcium nitrate, and magnesium nitrate, sodium chloride. Compositions with different contents of CaO, Na 2 O, and MgO were prepared. After maturation of the solutions, heat treatments were applied at 60 °C for 30 min; and followed by 600 °C and 800 °C for 1 h. Solution with 20 wt% MgO was found suitable for film production. The physicochemical processes of the formation of materials were studied, including the main stages: removal of physically bound and chemically bound water, combustion of alcohol and the products of thermo-oxidative destruction of ethoxy groups, and crystallization processes. The phase composition and structure of the films obtained were established at 600 °C and above when crystalline forms of SiO 2 , CaSiO 3 , Ca 2 P 2 O 7 , and complex phosphates were fixed. In the system with the addition of magnesium ions, β-cristobalite SiO 2 and stenfieldt Mg 3 Ca 3 (PO 4 ) 4 were detected; however, a crystalline sample could only be obtained at 800 °C. In the system with sodium ions, chemical compounds Ca 5 (PO 4 ) 3 Cl, NaCl, and SiO 2 were determined. A uniform film coating was formed on the surface of the substrate. The introduction of sodium oxide into the SiO 2 –P 2 O 5 –CaO system increased the bioactivity of the materials obtained.

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Calcium phosphate-based ceramic and composite materials for medicine

Cited by 142 publications

References 73 publications

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

Development of a biomaterial based on HAP/TiOy nanocomposite with different stoichiometry

The effect of sodium and magnesium ions on the properties of calcium–phosphate biomaterials

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