Calcium-peroxide-mediated cascades of oxygen production and glutathione consumption induced efficient photodynamic and photothermal synergistic therapy

Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) have been potent approaches to cancer treatment. However, the tumor microenvironment (TME) characterized by severe hypoxia and abundant glutathione (GSH) significantly reduces PDT's...

Multifunctional Nanoparticles for Enhanced Chemodynamic/Photodynamic Therapy through a Photothermal, H2O2-Elevation, and GSH-Consumption Strategy

“…With recent advancements in photochemistry and photoinduced therapy, multifunctional photosensitizers (PSs) have been reported and utilized in various combination therapies. − For instance, indocyanine green (ICG) and IR825 not only convert light energy into local heat during NIR-light irradiation for photothermal therapy (PTT) but also generate cytotoxic singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT). − Importantly, the photothermal effect of these PSs not only induces temperature rise but also accelerates the reaction rate and degree. Additionally, the local heat energy can be utilized to activate O 2 , leading to the production of 1 O 2 , further depleting GSH and inducing cell apoptosis. − However, the therapeutic efficacy of these PSs strongly depends on their accumulation behavior and the hypoxic condition in tumors, which can limit their application. Recent studies have discovered the generation of O 2 in CDT, which can mutually reinforce PDT. − Therefore, combining these PSs with CDT agents may accelerate and amplify oxidative stress, resulting in improved treatment outcomes. , …”

Flexible composite phase change materials with enhanced thermal conductivity and mechanical performance for thermal management

“…6,21 Among numerous studies on exible PCMs, exible PCMs based on polymer networks have gained popularity and will become the predominant trend of the future because of the diversities of polymer candidates and processing methods. 6 The exibility of PCMs based on polymer systems stems from elastic polymer molecular skeletons [22][23][24][25] or cross-linked polymer networks. [26][27][28][29] However, the low intrinsic thermal conductivity of organic solid-liquid PCMs and polymers makes exible composite PCMs containing polymer supporting structures suffer from a slow thermal response.…”

Anisotropic Black Phosphorene Structural Modulation for Thermal Storage and Solar‐Thermal Conversion

“…[2][3][4] However, the low thermal conductivity and insufficient photothermal conversion efficiency of commonly used PCMs, such as PEG, paraffin, and aliphatic acids, significantly restrict their broader applications in solar energy harvesting and thermal energy storage. [5][6][7] Therefore, there is an urgent need to simultaneously enhance the thermal conductivity and photothermal conversion efficiency of the phase change matrixes through the use of nanofillers. [8] In contrast to commonly used nanomaterials that can only enhance thermal conductivity or improve photothermal efficiency, the emerging black phosphorene (BP) is a promising candidate for achieving both targets simultaneously.…”