Calcium modulates the ATP and ADP hydrolysis in human placental mitochondria

Martı́nez, Federico; Uribe, Aída; Espinosa-García, María Teresa; Flores-Herrera, Óscar; Garcı́a-Pérez, Cecilia; Milán, Rebeca

doi:10.1016/s1357-2725(02)00020-1

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Cu is a centerpiece of reducing anti-oxidative stress ( Gaetke and Chow, 2003 ). Bone development and bone mass in humans are associated with Ca, whose intake in adequate amounts prevents fractures and osteoporosis ( Nordin, 1997 ; Martínez et al, 2002a ; Bass and Chan, 2006 ; Rizzoli et al, 2008 ). Similarly, K and Na are involved in all human tissues for ion transport across membranes; P and Mg are involved in cellular production of adenosine triphosphates (ATP); while S is critical to the biosynthesis of essential amino acids ( Martínez et al, 2002b ; Métayer et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic Dissection of ICP-Detected Nutrient Accumulation in the Whole Seed of Common Bean (Phaseolus vulgaris L.)

Blair

Bhandari

et al. 2016

Front. Plant Sci.

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Nutrient transport to grain legume seeds is not well studied and can benefit from modern methods of elemental analysis including spectroscopic techniques. Some cations such as potassium (K) and magnesium (Mg) are needed for plant physiological purposes. Meanwhile, some minerals such as copper (Cu), iron (Fe), molybdenum (Mo), and zinc (Zn) are important micronutrients. Phosphorus (P) is rich in legumes, while sulfur (S) concentration is related to essential amino acids. In this research, the goal was to analyze a genetic mapping population of common bean (Phaseolus vulgaris L.) with inductively coupled plasma (ICP) spectrophotometry to determine concentrations of and to discover quantitative trait loci (QTL) for 15 elements in ground flour of whole seeds. The population was grown in randomized complete block design experiments that had been used before to analyze Fe and Zn. A total of 21 QTL were identified for nine additional elements, of which four QTL were found for Cu followed by three each for Mg, Mn, and P. Fewer QTL were found for K, Na and S. Boron (B) and calcium (Ca) had only one QTL each. The utility of the QTL for breeding adaptation to element deficient soils and association with previously discovered nutritional loci are discussed.

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Section: Introductionmentioning

confidence: 99%

Genetic Dissection of ICP-Detected Nutrient Accumulation in the Whole Seed of Common Bean (Phaseolus vulgaris L.)

Blair

Bhandari

et al. 2016

Front. Plant Sci.

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“…Consequently, placental development and function requires increasing mitochondrial capacity to meet the increasing needs of the embryo. Placental mitochondria might play an important role in the maintenance of pregnancy and neonatal development through regulation of metabolic activity and adenosine triphosphate (ATP) production [2], hormone synthesis [3], and trophoblast oxygen sensing [4]. Mitochondrial dysfunction, induced by environmental toxins such as tobacco smoke [5] or maternal medical conditions such as preeclampsia [6], may cause cell damage and death by compromising ATP production, calcium homoeostasis and increased oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA Copy Number and Oxidative DNA Damage in Placental Tissues from Gestational Diabetes and Control Pregnancies: A Pilot Study

Qiu¹,

Hevner²,

Abetew³

et al. 2013

Clin. Lab.

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“…The mitochondria is an interesting organelle. It requires calcium in order to generate energy in the form of adenosine triphosphate (ATP) ( 38 , 39 ). It also serves as a calcium sink and can transiently buffer cytosolic calcium, as a cytoprotective mechanism ( 40 , 41 ).…”

Section: Discussionmentioning

confidence: 99%

Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells

Lange¹,

Moschny²,

Tamanyan³

et al. 2016

International Journal of Oncology

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Effective neuroblastoma (NB) treatments are still limited despite treatment options available today. Therefore, this study attempted to identify novel plant extracts that have anticancer effects. Cytotoxicity and increased intracellular calcium levels were determined using the Sulforhodamine B (SRB) assay and Fluo4-AM (acetoxymethyl) staining and fluorescence microscopy in NB cells in order to screen a library of plant extracts. The current study examined the anticancer effects of a dichloromethane extract from Scrophularia orientalis L. (Scrophulariaceae), a plant that has been used in Traditional Chinese Medicine. This extract contained highly potent agents that significantly reduced cell survival and increased calcium levels in NB cells. Further analysis revealed that cell death induced by this extract was associated with intracellular calcium release, opening of the MPTP, caspase 3- and PARP-cleavage suggesting that this extract induced aberrant calcium signaling that resulted in apoptosis via the mitochondrial pathway. Therefore, agents from Scrophularia orientalis may have the potential to lead to new chemo therapeutic anticancer drugs. Furthermore, targeting intracellular calcium signaling may be a novel strategy to develop more effective treatments for NB.

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Calcium modulates the ATP and ADP hydrolysis in human placental mitochondria

Cited by 7 publications

References 27 publications

Genetic Dissection of ICP-Detected Nutrient Accumulation in the Whole Seed of Common Bean (Phaseolus vulgaris L.)

Genetic Dissection of ICP-Detected Nutrient Accumulation in the Whole Seed of Common Bean (Phaseolus vulgaris L.)

Mitochondrial DNA Copy Number and Oxidative DNA Damage in Placental Tissues from Gestational Diabetes and Control Pregnancies: A Pilot Study

Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells

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