Calcium mitigates fluoride-induced kallikrein 4 inhibition via PERK/eIF2α/ATF4/CHOP endoplasmic reticulum stress pathway in ameloblast-lineage cells

Ptxplatin: a multifunctional Pt(iv) antitumor prodrug

“…As is known, the intracellular accumulation of ROS leads to the release of excessive Ca 2+ from the ER, 42 and Ca 2+ overload causes ER dysfunction. 43 Therefore, Fluo-4 AM, a Ca 2+ indicator dye, was used to estimate the change of the Ca 2+ level after 5 -treated MCF-7 for 24 h. As shown in Fig. 6a, the green fluorescence of Ca 2+ was significantly upregulated after treatment with 5 than that of CDDP, PTX and their combination (1 : 1), indicating that the intracellular Ca 2+ concentration was significantly increased in a concentration-dependent manner when MCF-7 cells were treated with compound 5 .…”

Structure and Function of Mitochondria‐Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases

“…PERK is involved in the maintenance of the mitochondria-ER contacts and enhancement of the ROS-induced mitochondrial apoptosis. Once MFN2 is depleted, PERK is activated, and the PERK-EiF2α-ATF4-CHOP pathway is enhanced (Figure 2(c)) [80]. Studies have suggested that ATF6 interacts with the tethering protein VAPB to suppress the UPR directly.…”

Advances in epidemiological status and pathogenesis of dental fluorosis

“…Recent studies have shown that it can affect the function of ameloblasts in the following ways: 1) Fluoride mediates the release of Ca 2+ from the endoplasmic reticulum of ameloblasts via inositol 1,4,5-trisphosphate receptors (Aulestia et al, 2020). Studies have shown that in a high-fluoride environment, compared with the control group, Ca 2+ can increase the activity of KLK-4, improve the inhibitory effect of fluoride on ameloblast growth, and reduce apoptosis, which is related to the activation of the protein kinase R-like endoplasmic reticulum kinase-eukaryotic initiation factor 2 α-activating transcription factor 4-C/EBP homologous protein pathway (Liu et al, 2021).…”