Calcium Metabolism in Pre- and Postmenopausal Morbidly Obese Women at Baseline and After Laparoscopic Roux-En-Y Gastric Bypass

El-Kadre, Luciana; Rocha, Paulo Roberto Savassi; Tinoco, Augusto; Tinoco, Renam Catharina

doi:10.1381/0960892041975505

Cited by 84 publications

(71 citation statements)

References 20 publications

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“…One hypothesis is that vitamin D is stored by the fatty tissue of obese patients and that it may be gradually released into the circulation during weight loss (11). However, contrary to common belief, there is no significant improvement in 25OHD status after bariatric surgery, as illustrated by several longitudinal studies (16,17,(33)(34)(35)(36). This was confirmed by the present study, in which no significant differences in the serum 25OHD levels were recorded in patients submitted to bariatric surgery.…”

Section: Discussionsupporting

confidence: 73%

Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity

Vasconcelos

Viégas

Marques

et al. 2010

Arq Bras Endocrinol Metab

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OBJECTIVE: To evaluate bone metabolism, bone density (BMD) and vertebral fractures in morbidly obese individuals. SUBJECTS AND METHODS: Case series of 29 premenopausal obese patients, 15 of whom had been submitted to bariatric surgery. Serum calcium, albumin, PTH and 25-hydroxy vitamin D (25OHD) were measured as well as bone densitometry of the lumbar spine and proximal femur, and lateral spine x-rays. RESULTS: High parathyroid hormone (PTH) levels were recorded in 46.6% of the surgical patients and in 21.4% of the non-surgical patients (p = 0.245); 26.7% of the former and 28.6% of the latter revealed levels 25OHD < 30 ng/mL (p = 1.000). Calcium intake was higher in the surgical group (p = 0.004) along with lower serum calcium concentrations (p = 0.019). There were no significant differences in bone mineral density (BMD) or in the prevalence of vertebral fractures between groups. CONCLUSION: In premenopausal women undergoing Roux-en-Y gastric bypass there is important intestinal calcium mal absorption which seems to be the main factor causing secondary hyperparathyroidism.

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Section: Discussionsupporting

confidence: 73%

Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity

Vasconcelos

Viégas

Marques

et al. 2010

Arq Bras Endocrinol Metab

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“…Our finding of a significant increase in bone resorption in the year after RYGB is consistent with previous reports [Grethen et al 2012, Bruno et al 2010, El Kadre et al 2004, Casagrande et al 2012, Coates et al 2004, Stein et al 2013, Biagioni et al 2013, Sinha et al 2011, Mahdy et al 2008. Also, as we Carrasco et al 2009, Gomez et al 2009, Holdstock et al 2003 observed in the post-operative period.…”

supporting

confidence: 92%

Effects of endocrine and inflammatory changes on markers of bone turnover following Roux-en-Y gastric bypass surgery

Rogers¹,

Havel²,

Wolfe³

et al. 2015

MRAJ

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“…Interestingly, there is no significant improvement in 25(OH)D status after bariatric surgery, as reported by a number of authors (31)(32). Also, although some studies have mentioned a significant increase in 25(OH)D, levels have remained at suboptimum values, which may contribute to maintaining a state of SHPT (33).…”

Section: Discussionmentioning

confidence: 89%

Bariatric surgery and bone metabolism: a systematic review

Viégas

Vasconcelos

Neves

et al. 2010

Arq Bras Endocrinol Metab

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SUMMARYFew studies have demonstrated the risk of metabolic bone disease and a reduction in bone mineral density (BMD) after bariatric surgery. A systematic review was conducted of case-control and cohort studies with the aim of evaluating the relationship between bariatric surgery and bone metabolism. The search was undertaken in MedLine, covering the period from January 1997 to August 2009, using the keywords: "bariatric surgery" AND "osteoporosis" , "fracture" , "bone diseases" , "metabolic" . Six studies were included, comprising four cohort and two casecontrol studies. Three studies evaluated bone metabolism and BMD, and the other evaluated bone metabolism only. Based on this review, bariatric surgery is associated with alterations in bone metabolism, loss of bone mass and an increased risk of fracture. However, the maximum evaluation period covered by these studies was two years after surgery, hence the need to undertake further studies of longer duration in order to achieve a more thorough understanding of this association. Arq Bras Endocrinol Metab. 2010;54(2):158-63 Keywords Osteoporosis; fracture; bariatric surgery; bone diseases SUMÁRIO Alguns estudos têm demonstrado aumento do risco de doença osteometabólica e redução de densidade mineral óssea (DMO) após a cirurgia bariátrica. Realizou-se uma revisão sistemática de estudos de caso-controle e coorte com o objetivo de avaliar a relação entre cirurgia bariátri-ca e o metabolismo ósseo. A procura foi realizada na MedLine de janeiro 1997 a agosto 2009, utilizando os descritores: "bariatric surgery" e "osteoporosis" , "fracture" , "bone diseases" , "metabolic" . Foram incluídos seis estudos, sendo quatro coortes e dois casos-controle. Três desses estudos avaliaram metabolismo ósseo e DMO e os demais avaliaram apenas o metabolismo ósseo. Com base nesta revisão, a cirurgia bariátrica está associada com alterações no metabolismo ósseo, perda de massa óssea e aumento no risco de fraturas. Entretanto, os estudos tiveram acompanhamento máximo de dois anos após a cirurgia, havendo necessidade de estudos de maior seguimento para melhor conhecimento dessa associação. Arq Bras Endocrinol Metab. 2010;54(2):158-63

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Calcium Metabolism in Pre- and Postmenopausal Morbidly Obese Women at Baseline and After Laparoscopic Roux-En-Y Gastric Bypass

Abstract: Calcium metabolism is altered in pre- and post-menopausal women following LRYGBP. Calcium and vitamin D supplementation is strongly advised in all patients.

Cited by 84 publications

References 20 publications

Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity

Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity

Effects of endocrine and inflammatory changes on markers of bone turnover following Roux-en-Y gastric bypass surgery

Bariatric surgery and bone metabolism: a systematic review

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