Calcium Metabolism and Bone Changes in Sarcoidosis

Mather, Gordon

doi:10.1136/bmj.1.5013.248

Cited by 43 publications

(18 citation statements)

References 18 publications

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“…David, Verner, and Engel, 1962). Mather (1957) found only four with hypercalcaemia in 86 untreated cases of sarcoidosis, and concluded that the condition occurs so infrequently in patients not receiving vitamin D, that routine estimation of the serum calcium was unnecessary. In Case 10 the serum calcium and phosphorus became normal within 4 weeks, after corticosteroid treatment of the severe ocular and pulmonary involvement.…”

Section: Discussion Biopsiesmentioning

confidence: 99%

Sarcoidosis with Arthritis

Bianchi¹,

Keech²

1964

Annals of the Rheumatic Diseases

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Section: Discussion Biopsiesmentioning

confidence: 99%

Sarcoidosis with Arthritis

Bianchi¹,

Keech²

1964

Annals of the Rheumatic Diseases

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“…The well-known investigations of Anderson et al (1954), Henneman et al (1956), Mather (1957), Jackson & Dancaster (1959) and Bell, Gill & Bartter (1964) comprise a total of twelve patients with both hypercalcaemia and hypercalciuria, and three with hypercalciuria; many had impaired renal function. In these patients, low faecal calcium was consistently demonstrated, supporting the theory that calcium absorption from the gut is increased in sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, most investigators have accepted the concept that patients with this disease are abnormally sensitive to vitamin D. Evidence for this view includes reports of toxicity from use of calciferol in sarcoidosis (Scadding, 1950;Mather, 1957), observations of adverse effects of sunlight (Ellman & Parfitt, 1960) and the report of increased frequency of hypercalcaemia in summer months (Taylor et al, 1963). The effect of sunlight, however, has not been confirmed in two prospective studies; the toxic effects of calciferol may be independent of hypercalcaemia (Robertson, 1948); and we have used calciferol in treatment of several patients with disfiguring cutaneous sarcoids; no increases in calcium levels occurred.…”

Section: Discussionmentioning

confidence: 99%

Frequency of disordered calcium metabolism in sarcoidosis

Israel

Goldstein

1970

Postgraduate Medical Journal

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“…Many are discovered by x-ray only. Even with obvious deformity, pain is usually minimal (3,6,8,10). Osseous lesions have never been specifically noted in the literature as the sole manifestation of sarcoidosis, although some early European reports (1,2) imply this possibility in a few cases prior to the routine use of chest radiography.…”

Section: Discussionmentioning

confidence: 99%

“…multiorgan involvement tend toward the higher incidence figures (3-8). The low incidence series (< 5y0) (9)(10)(11)(12) are weighted with early cases, especially with bilateral hilar adenopathy, erythema nodosum, and a low incidence of skin lesions. The clinical presentation of osseous sarcoid is most remarkable by its absence of symptoms in most cases.…”

Section: Discussionmentioning

confidence: 99%

Extensive phalangeal cystic lesions

Schriber

Firooznia

1975

Arthritis & Rheumatism

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A young black man is presented with a 33-month course of insidious but eventually striking hand deformity and limitation of motion in the absence of any other symptoms. Radiologic and histologic findings of the digits support the diagnosis of sarcoidosis, though physical, laboratory, and chest x-ray examination show no evidence of this multisystem disease.Osseous involvement is a well-recognized feature of sarcoidosis, occurring rarely in the absence of skin lesions or chronic, multiorgan system involvement. When present it is usually not symptomatic. A patient was presented with complaints limited to the hands and feet throughout a 33-month course. The possibility is raised that, in rare instances, sarcoid may be limited to the skeletal system. The patient was well until January 1971 when he noted swelling and mild discomfort in the area of the second left metacarpophalangeal joint, which lasted several days and resolved. This condition recurred soon afterward in several areas of both hands. At all times, swelling was the predominant feature, although there was mild discomfort at times, especially in the morning. He came to the outpatient department at Bellevue Hospital in early 1971 for this complaint. Radiographic examination of the hands showed several cystic bony lesions, but the patient did not return for further workup or treatment. CASE REPORTDuring the next 19 months he noted persistent swelling of the fingers with occasional mild discomfort and morning stiffness. However, he was not greatly bothered and continued his activities as a student, even playing basketball occasionally. He sought no medical attention during this time. I n the summer of 1972, the patient noted that the swelling increased and that he now had difficulty performing certain fine movements because of relatively painless limited motion. When school started in September 1972, he noted he could not hold a pencil properly and sought medical attention for the second time at Bellevue Hospital. Pain was never a major feature and there were no acute at tacks.There was no history of fever, malaise, rash, other musculoskeletal complaints, visual disturbances, cough, or shortness of breath. Past medical history and family history were noncontributory. On admission to Bellevue Hospital in September 1972, physical examination revealed a wellnourished, well-developed black man who appeared healthy, except for obviously swollen, sausage-like fingers. Vital signs, head, eyes, ears, nose, and throat were normal. There were no skin lesions. There were several y2 X v2 cm soft, movable, nontender nodes in both axillae. The chest cage, heart, and lungs were normal. The abdomen showed no organo-

show abstract

Calcium Metabolism and Bone Changes in Sarcoidosis

Cited by 43 publications

References 18 publications

Sarcoidosis with Arthritis

Sarcoidosis with Arthritis

Frequency of disordered calcium metabolism in sarcoidosis

Extensive phalangeal cystic lesions

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