Calcium-Mediated Effects of Cyclic GMP on the Stimulation of Thymocyte Proliferation by Prostaglandin E1

Whitfield, J. F.; MacManus, J. P.

doi:10.3181/00379727-139-36244

Cited by 13 publications

(3 citation statements)

References 6 publications

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“…E-type prostaglandins stimulated adenyl cyclase in lymphocytes (258)(259)(260)(261)(262)(263)(264), leucocytes (265), turkey erythrocytes (266), and platelets (267)(268)(269), cf also the platelet section) and potentiated the effect of erythropoietin in bone marrow cell cultures probably by activating adenyl cyclase (270). The increased cAMP levels prevented lymphocyte transformation (258), blocked the lymphocyte cytotoxic effect (260), inhibited platelet aggregation (271), and prevented immediate as well as delayed hypersensitivity in vitro (272).…”

Section: Blood and Bone Marrow Cellsmentioning

confidence: 99%

Prostaglandins

Samuelsson¹,

Granström²,

Green³

et al. 1975

Annu. Rev. Biochem.

567

170

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Section: Blood and Bone Marrow Cellsmentioning

confidence: 99%

Prostaglandins

Samuelsson¹,

Granström²,

Green³

et al. 1975

Annu. Rev. Biochem.

567

170

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“…Measurable molecular lesions in all stages of liver neoplasia include modifications in the hormonal control of structural gene expression [16,31,64,66,105,146,273,340,345,349]. Modifications of this kind have been observed with both polypeptide and steroid hormones in many different tumor systems [9,30,87,90,145,187,195,201,225,292].…”

Section: Introductionmentioning

confidence: 99%

“…92, 132, 133, 138-140, 154, 163-165, 184, 191, 205, 209, 234, 236, 277, 287, 297, 299, 305, 306, 311, 324, 338, 347, 348, 356, 359, 360], Another cyclic nucleotide, cyclic 3',5'-guanosine monophosphate, has only recently been identified in urine and tissues. Numerous studies have now begun in attempts to elucidate its biological functions [96,98,99,214,345], These two nucleo tides, cyclic AMP and cyclic GMP, appear to be the only natural occurring 3',5'-cyclic nucleotides. Numerous investigations of the physiological involvement of these two cyclic nucleotides as intracellular second messengers of extracellular hormone action have revealed the following complex system of components: membrane receptors for hormones; adenyl cyclases; guanyl cyclases; cAMP; cGMP; cAMP and cGMP phosphodiesterases ( + modulators); cAMP and cGMP binding proteins; cyclic nucleotide responsive protein kinases ( + modulators), which are independent, de pendent upon cAMP, and/or dependent upon cGMP, and phosphoprotein phosphatases ( fig.…”

Section: Introductionmentioning

confidence: 99%

Second Messenger System in Neoplasia

Criss¹

1974

Oncology

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Hormones have been observed to initiate tumors in animals and are thought to be involved in cellular selection and/or progression of neoplastic lesions in humans. Hormones are the ‘First messengers’ in mammalian systems as they allow cell to cell and organ to organ communication A ‘second messenger’ system is currently being elucidated. This second messenger system involves several cellular membraneous and intracellular components which act to relay extracellular messages to intracellular targets including the genomic machinery within the nucleus. The current manuscript reviews and discusses the following components of the second messenger system in normal versus neoplastic tissues: hormone binding, message transduction, adenylate cyclases, guanylate cyclases, cyclic AMP, cyclic GMP, cyclic nucleotide phosphodiesterases, cyclic nucleotide binding proteins, protein kinases (protein phosphorylation), and phosphoprotein dephosphatases (phosphoprotein de-phosphorylation).

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Calcium‐mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E₁

Whitfield

MacManus

Franks

et al. 1972

Journal Cellular Physiology

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The calcitonin (SCT) from salmon ultimobranchial bodies which (like mammalian calcitonins) lowers the plasma calcium concentration i n mammals can also affect cyclic AMP (cyclic adenosine 3',5'-monophosphate) metabolism and proliferation of lymphoblasts in normal and prostaglandin El (PGE1)-treated rat thymocyte populations in three different ways. In the first case, low concentrations (0.5-5.0 ng per milliliter) of SCT lower (by a calciummediated process) the ability of PGEl to transiently increase cyclic AMP synthesis, but the reduced surge of cyclic AMP production is still ample to stimulate lymphoblasts in the cell population to initiate deoxyribonucleic acid (DNA) synthesis. Secondly, these low SCT concentrations affect the eventual progression of the PGEl-stimulated, DNA-synthesizing lymphoblasts into mitosis by a calcium-mediated process. Depending on the extracellular calcium concentration and the magnitude of the initial increment in the intracellular cyclic AMP content, SCT can either promote or inhibit the progression of the stimulated cells into mitosis. SCTs third action is a rapid (within 5 minutes), calcium-independent elevation of the cellular cyclic AMP content in otherwise untreated thymic lymphocyte populations exposed to a very high concentration (100 ng per milliliter) of the hormone. This early, transient rise in the cyclic AMP level is followed by a calcium-dependent increase in lymphoblast proliferation, An attempt is made to interrelate and explain the different actions of SCT on cyclic AMP metabolism and mitogenesis.

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Calcium-Mediated Effects of Cyclic GMP on the Stimulation of Thymocyte Proliferation by Prostaglandin E1

Cited by 13 publications

References 6 publications

Prostaglandins

Prostaglandins

Second Messenger System in Neoplasia

Calcium‐mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E₁

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Calcium-Mediated Effects of Cyclic GMP on the Stimulation of Thymocyte Proliferation by Prostaglandin E1

Cited by 13 publications

References 6 publications

Prostaglandins

Prostaglandins

Second Messenger System in Neoplasia

Calcium‐mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E1

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Calcium‐mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E₁