Calcium Ionophore A23187 and Compound 48/80 Induce PGD2 and Tryptase in Human Cord Blood-Derived Mast Cells: Lack of Effect of IL-18

Maccauro, Giulio; Tripodi, Domenico; Saggini, Andrea; Conti, Francesca; Cianchetti, Ettore; Angelucci, Domenico; Rosati, M; Toniato, E; Fulcheri, Mario; Tetè, Stefano; Salini, Vincenzo; Caraffa, Alessandro; Antinolfi, Pierluigi; Frydas, S.; Conti, Pio; Theoharides, Theoharis C.

doi:10.1177/1721727x1201000104

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…This chemokine is important for the recruitment of T cells and DCs in atopy [48]. In contrast, however, cord-derived mast cells did not increase release of prostaglandin D2 or tryptase in response to treatment with IL-18 [49]. Basophils increase IgE- and A23187-induced release of leukotrienes B 4 and C 4 after culture in IL-3 or IL-18 (but not IL-4, IL-6, or IL-13) in a dose dependent manner, with the effects of IL-3 exceeding the effects of IL-18.…”

Section: Role Of Il-18 In Allergic Diseasementioning

confidence: 99%

Role of interleukin-18 in the pathophysiology of allergic diseases

Sanders

Mishra

2016

Cytokine & Growth Factor Reviews

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Interleukin (IL)-18 is an IL-1 family cytokine expressed by macrophages, dendritic cells, epithelial cells, and keratinocytes and is implicated in various aspects of both the innate and adaptive immune systems. IL-18 signals similar to IL-1β intracellularly to activate gene transcription. Since its discovery, IL-18 has been demonstrated to play a key role in pathogen defense from helminths and some bacteria. Recently however, evidence has accumulated that IL-18 expression is increased in many presentations of allergic disease. A pathologic role for IL-18 includes stimulating mast cell and basophil degranulation, recruiting granulocytes to sites of inflammation, increasing cytotoxic activity of natural killer (NK) and NK-T cells, inducing Immunoglobulin (Ig)E production and isotype switching, and affecting a broad range of T cells to promote a type II helper T cell (Th2) response. Evidence and importance of these effects are presented, including novel results from our lab implicating IL-18 in the direct expansion of mast cells, basophils, and other myeloid-lineage cells from bone-marrow precursors. The development of urticaria, asthma, dermatitis, rhinitis, and eosinophilic disorders all have demonstrated correlations to increased IL-18 levels either in the tissue or systemically. IL-18 represents a novel site of immune regulation in not only allergic conditions, but also autoimmune diseases and other instances of aberrant immune functioning. Diagrammatic summarized abstract for readers convinanceis presented in figure 1.

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Section: Role Of Il-18 In Allergic Diseasementioning

confidence: 99%

Role of interleukin-18 in the pathophysiology of allergic diseases

Sanders

Mishra

2016

Cytokine & Growth Factor Reviews

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“…The most recent addition to the ever-growing family of cytokines include interleukin-38 which was first identified by Haishan Lin and Bensen JT, et al (52)(53)(54)(55)(56). These authors show that IL-38 is a member of the IL-l family, in fact, the novel IL-l-like gene, IL-IFIO, is located on human chromosome 2q13-14.l near the IL-l receptor antagonist gene (57)(58)(59)(60).…”

Section: Il-38 (Il-lflo)mentioning

confidence: 99%

IL-36 Receptor Antagonist with Special Emphasis on IL-38

Shaik

Sabatino

Maccauro

et al. 2013

Int J Immunopathol Pharmacol

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IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

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“…CCL2/MCP-1 is a small (8000-10000 MW) protein and is one of the major and most studied members of the CC chemokine beta subfamily. The roles of CCL2/MCP-1 is emerging in regulating the recruitment of inflammatory cells into tissue during inflammation and allergy [46,47]. CCL2/MCP-1 is one of the major and most studied members of the CC chemokine beta subfamily.…”

Section: Chemokine Ccl2/mcp-1mentioning

confidence: 99%

Role of TNF Alpha, IL-33 and CCL2/MCP-1 in Mast Cell Activity

Conti¹

2013

Glob. J. Immunol. Allerg. Dis.

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Mast cells are the derivatives of hematopoietic progenitor cells and play an important role in immediate Type I hypersensitivity and late phase reactions but also in innate immunity (3), allergy and inflammation (4) by secreting a large variety of chemical mediators either from storage sites in their granules, or producing immuno-regulatory proteins upon stimulation (5-14). They directly interact with bacteria and appear to play a vital role in host defense against pathogens. The addition of certain cytokines to human umbilical cord blood-derived cultured mast cells shown to augment IgE-induced production of distinct cytokines, without histamine secretion. Mast cells could be recruited in the inflammatory site, by MCP-1, RANTES and SCF, and selectively secrete proinflammatory molecules; these could include growth factors, histamine, which is mitogenic (H1) and an immunosuppressant (H2), neovascularization agents, such as heparin, IL-8, and VEGF as well as proteases that could permit new blood vessel formation. IL-33 belongs to the IL-1 family and binds to the ST2 receptor which has high homology to IL-1 receptor and has biological activities. IL-33, causes allergic inflammation and exerts significant biological effects both in vivo and in vitro. IL-33 induces expression of several cytokine and chemokine, resulting in severe inflammatory and allergic diseases. Using human umbilical cord blood mast cells (HUCBMCs), as a valid model, we found that IL-33 induces CCL2/MCP-1 release in HUCBMCs. This study documents the ability of IL-33 to directly stimulate HUCBMCs to produce CCL2/MCP-1. We reported that IL-33 is a strong activator of human mast cell capable to induce CCL2/MCP-1 released at translational level. The data described an additional biological activity of IL-33, suggesting that this cytokine may have an important effect on the recruitment of inflammatory cells in allergic diseases. IL-33 may be also critically involved in regulation of cyclooxygenase production in vitro and probably in vivo, providing a potential therapeutic target for inflammatory diseases. CCL2 monocytes chemotactic protein 1 (MCP-1) is a potent chemotactic molecule that attracts lymphocytes, monocytes, mast cells, and memory T cells, but not neutrophils. In this review we highlighted, for the first time, the importance of TNF alpha, IL-33, and MCP-1 in mast cell activity.

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Calcium Ionophore A23187 and Compound 48/80 Induce PGD2 and Tryptase in Human Cord Blood-Derived Mast Cells: Lack of Effect of IL-18

Cited by 3 publications

References 49 publications

Role of interleukin-18 in the pathophysiology of allergic diseases

Role of interleukin-18 in the pathophysiology of allergic diseases

IL-36 Receptor Antagonist with Special Emphasis on IL-38

Role of TNF Alpha, IL-33 and CCL2/MCP-1 in Mast Cell Activity

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