Calcium intake and breast cancer risk: meta-analysis of prospective cohort studies

Hidayat, Khemayanto; Chen, Guo‐Chong; Zhang, Ru; Du, Xuan; Zou, Sheng‐Yi; Shi, Bimin; Qin, Li–Qiang

doi:10.1017/s0007114516001768

Cited by 40 publications

(27 citation statements)

References 51 publications

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“…calcium chloride, calcium sulfate), and calcium may serve as a potential regulator in breast cancer cell proliferation [52]. A meta-analysis of eleven prospective cohort studies suggest an inverse dose-response association between calcium intake and breast cancer risk [53].…”

Section: Discussionmentioning

confidence: 99%

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

2020

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Observational studies on the association between tofu intake and breast cancer incidence have reported inconsistent results. We reviewed the current evidence and quantitatively assessed this association by conducting a dose-response meta-analysis. The electronic databases PubMed and EMBASE were searched for relevant studies published up to August, 2018. We included epidemiological studies that reported relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) for the association between tofu intake and breast cancer risk. A total of 14 studies (2 cohort studies, 12 case-control studies) were included in the meta-analysis. The overall OR of breast cancer for highest vs lowest intake of tofu was 0.78 (95% CI 0.69-0.88), with moderate heterogeneity (P = 0.011, I 2 = 49.7%). Dose-response analysis based on 5 case-control studies revealed that each 10 g/d increase in tofu intake was associated with 10% reduction in the risk of breast cancer (95% CI 7%-13%, P = 0.037, I 2 = 40.8%). In summary, our findings suggest an inverse doseresponse association between tofu intake and risk of breast cancer. However, owing to the limitations of case-control studies, more properly designed prospective studies are warranted to confirm this association.PLOS ONE | https://doi.org/10.1371/journal.pone.0226745 January 7, 2020 1 / 13 OPEN ACCESSCitation: Wang Q, Liu X, Ren S (2020) Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies. PLoS ONE 15(1): e0226745. https://doi.org/10.

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Section: Discussionmentioning

confidence: 99%

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

2020

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“…Numerous studies have investigated the association between dietary calcium intake and various cancer risks. Previous meta-analyses have found that dietary calcium intake might have a protective effect on colorectal cancer (RR = 0.86, 95% CI = 0.78–0.95) [44] and breast cancer (RR = 0.92, 95% CI = 0.85–0.99) [45], but have an opposite influence on the risk of prostate cancer (RR = 1.18, 95% CI = 1.08–1.30) [46], while having no significant relationship with the risk of lung cancer (RR = 0.85, 95% CI = 0.63–1.13) [47]. The findings presented in this meta-analysis add new information regarding the association between calcium intake and cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Dietary Calcium Intake on Esophageal Cancer Risk: A Meta-Analysis of Observational Studies

Cui

Tian

et al. 2017

Nutrients

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Although several epidemiological studies have investigated the association between dietary calcium intake and the risk of esophageal cancer, the results are inconsistent. This study aimed to make a comprehensive evaluation regarding the association between calcium intake and risk of esophageal cancer through a meta-analysis approach. We searched for all relevant articles from the inception to April 2017, using PUBMED, EMBASE, and Web of Knowledge. The pooled odds ratio (ORs) with the 95% confidence interval (95% CI) for the highest versus the lowest categories of calcium intake was calculated using a Mantel–Haenszel fixed-effect model. In total, 15 articles reporting 17 studies including 3396 esophageal cancer cases and 346,815 controls were selected for the meta-analysis. By comparing the highest vs. the lowest levels of dietary calcium intake, we found that dietary calcium intake was inversely associated with the risk of esophageal cancer (OR = 0.80, 95% CI: 0.71–0.91, I2 = 33.6%). The subgroup analysis indicated that the protective function of dietary calcium intake were observed in esophageal squamous cell cancer, but not in esophageal adenocarcinoma in the studies conducted in Asia, but not those in Europe and America. In conclusion, our results suggest that higher dietary calcium intake is associated with a lower risk of esophageal cancer—especially esophageal squamous cell cancer—in Asian populations, though more data from prospective cohort studies are needed.

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“…An inverse dose–‐response association between calcium intake and breast cancer risk was described. A large meta‐analysis of eleven prospective studies showed that the overall risk reduction in breast cancer for high versus low intake of calcium was 0.92 (95% CI 0.85, 0.99) . Two recent meta‐analysis of prospective studies showed that overall vitamin D blood levels are associated with reduced breast cancer risk .…”

Section: Introductionmentioning

confidence: 99%

Correlation of mammographic density and serum calcium levels in patients with primary breast cancer

et al. 2017

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Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well‐known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P < 0.001) and age (P < 0.001). There was also an association between PMD and menopausal status (P < 0.001). The goodness‐of‐fit of the regression model was moderate. This is the first study assessing the association between serum calcium level and PMD. An inverse association with adjusted serum calcium levels was observed. These findings add to previously published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.

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Calcium intake and breast cancer risk: meta-analysis of prospective cohort studies

Cited by 40 publications

References 51 publications

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

Protective Effect of Dietary Calcium Intake on Esophageal Cancer Risk: A Meta-Analysis of Observational Studies

Correlation of mammographic density and serum calcium levels in patients with primary breast cancer

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