Calcium Hydroxyapatite Fillers

Tansavatdi, Kristina; Mangat, Devinder S.

doi:10.1055/s-0031-1298783

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…It is similar to the inorganic constituents of human bone in chemical composition and physical properties and is one of the most mature orthopedic biomaterials used to promote osteogenesis; therefore, it was used as a control in the experiments. However, its degradation rate and osteogenic performance are deficient, and it is expensive (20-23). …”

Section: Discussionmentioning

confidence: 99%

An animal experimental study of porous magnesium scaffold degradation and osteogenesis

Liu

Yang

Tan

et al. 2014

Braz J Med Biol Res

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Our objective was to observe the biodegradable and osteogenic properties of magnesium scaffolding under in vivo conditions. Twelve 6-month-old male New Zealand white rabbits were randomly divided into two groups. The chosen operation site was the femoral condyle on the right side. The experimental group was implanted with porous magnesium scaffolds, while the control group was implanted with hydroxyapatite scaffolds. X-ray and blood tests, which included serum magnesium, alanine aminotransferase (ALT), creatinine (CREA), and blood urea nitrogen (BUN) were performed serially at 1, 2, and 3 weeks, and 1, 2, and 3 months. All rabbits were killed 3 months postoperatively, and the heart, kidney, spleen, and liver were analyzed with hematoxylin and eosin (HE) staining. The bone samples were subjected to microcomputed tomography scanning (micro-CT) and hard tissue biopsy. SPSS 13.0 (USA) was used for data analysis, and values of P<0.05 were considered to be significant. Bubbles appeared in the X-ray of the experimental group after 2 weeks, whereas there was no gas in the control group. There were no statistical differences for the serum magnesium concentrations, ALT, BUN, and CREA between the two groups (P>0.05). All HE-stained slices were normal, which suggested good biocompatibility of the scaffold. Micro-CT showed that magnesium scaffolds degraded mainly from the outside to inside, and new bone was ingrown following the degradation of magnesium scaffolds. The hydroxyapatite scaffold was not degraded and had fewer osteoblasts scattered on its surface. There was a significant difference in the new bone formation and scaffold bioabsorption between the two groups (9.29±1.27 vs 1.40±0.49 and 7.80±0.50 vs 0.00±0.00 mm3, respectively; P<0.05). The magnesium scaffold performed well in degradation and osteogenesis, and is a promising material for orthopedics.

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Section: Discussionmentioning

confidence: 99%

An animal experimental study of porous magnesium scaffold degradation and osteogenesis

Liu

Yang

Tan

et al. 2014

Braz J Med Biol Res

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“…Given the discomfort and downtime associated with Le Fort osteotomies, few patients elect to undergo these procedures for the purpose of midface enhancement but they are mentioned herein for completeness. Temporary and permanent softtissue fillers and microfat grafting have also been employed in the augmentation of facial softtissues [19][20][21]. Although these techniques have demonstrated efficacy, they do not directly address skeletal inadequacy and when chosen in lieu of addressing skeletal limitations, may not yield optimal patient satisfaction [14 & ].…”

Section: Midfacial Augmentationmentioning

confidence: 99%

Implants in facial skeletal augmentation

Brandt

Moore

2013

Current Opinion in Otolaryngology & Head and Neck Surgery

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“…The rationale for this preference is not only targeting different layers of the face but also improved quality and thickness of the overlying skin would avoid the need for volume enhancement in certain facial regions. 1,2 The efforts to produce the ideal filler material are still ongoing. Different soft tissue fillers have their advantages and drawbacks.…”

mentioning

confidence: 99%

The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Form

et al. 2023

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INTRODUCTION Biostimulation properties of diluted and hyperdiluted calcium hydroxylapatite (CaHA) injections have become increasingly popular. However, the existing data are insufficient to certify a particular dose–response pattern. OBJECTIVE To assess and compare the dermal stimulation potentials of different concentrations of CaHA injections. MATERIALS AND METHODS Two independent experiments (Experiment-1: constant injection volume vs Experiment-2: constant CaHA amount) included 4 study groups each, and these experimental groups were placed consecutively on the abdominal skin of a juvenile Yorkshire pig. Histopathological and immunohistochemical stainings were performed on punch biopsy materials collected 4 months after the injection day. RESULTS The fibroblast count significantly decreased upon dilution from 1:3 to 1:19 in experiment 1 (p = .000) but still higher than the control group. In experiment 1, the collagen density of the concentrated form was more elevated than the 1:19 dilution and the negative control groups (p = .034 and .000, respectively) but similar to the 1:3 dilution (p = .123). No significant difference was observed between the groups regarding collagen density with a standard amount of CaHA (0.2 mL, 30%) (p > .05). CONCLUSION Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group.

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Calcium Hydroxyapatite Fillers

Cited by 14 publications

References 13 publications

An animal experimental study of porous magnesium scaffold degradation and osteogenesis

An animal experimental study of porous magnesium scaffold degradation and osteogenesis

Implants in facial skeletal augmentation

The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Form

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