Calcium Fructoborate—Potential Anti-inflammatory Agent

Abstract

Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1β, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-α production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1-7 mg calcium fructoborate (0.025-0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.

Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy

“…CF is efficient in the prevention and treatment (as adjuvant) of osteoporosis and osteoarthritis (Peng et al, 2000;Miljkovic et al, 2009;Scorei & Rotaru, 2011). In addition, CF has shown inhibitory effects on MDA-MB-231 breast cancer cells (Scorei et al, 2008;Scorei & Rotaru, 2011). CF most likely enters the cell through a co-transport mechanism via a sugar transporter (Miljkovic et al, 2009).…”

Simultaneous Quantitation of Boric Acid and Calcium Fructoborate in Dietary Supplements by HPTLC-Densitometry

“…[7][8][9] CFB is a patented plant mineral compound, which is displayed and sold as bulk as a nutritional supplement under the name of FruiteX-B ® (FrxB), 10 a nature-identical analogue of a plant mineral complex with potential health benefits for conditions associated with inflammation of the bone, joint and cardiovascular system. [6][7][8][9][10][11][12] In the past, quantification of boronic/boric/borate esters has been performed using liquid and solid 11 B-NMR, 11,13,14 TLC, [15][16][17] HPLC coupled with UV or fluorometric detection, 18 thermal analysis, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman and inductively coupled plasma (ICP) spectroscopy 19 either alone or in combination with other compounds.…”

Genotoxicity and Cytotoxicity of novel 10B carrier ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid

“…Henderson and co-workers confirmed that a high level of boric acid in the blood reduces the risk of prostate cancer by reducing the level of Ca ++ in cells and signal transmission [33]. Scorei and co-workers demonstrated the antiproliferative effects of boric acid and calcium fructoborate (the form of boron in food) in breast cancer cells and also showed that calcium fructoborate induces apoptosis [34]. Hsu and co-workers showed that boric acid may be helpful for the treatment of bone cancers because it has cytotoxic effects and it accumulates in bones [19].…”