Calcium dobesilate versus purified flavonoid fraction of diosmin in the treatment of hemorrhoidal crises: a randomized, controlled study with an initial double-blind, double-dummy period

Calcium Dobesilate Versus Flavonoids for the Treatment of Early Hemorrhoidal Disease: A Randomized Controlled Trial

“…Furthermore, a decrease in the size of hemorrhoids was seen in 67.3% patients after treatment with flavonoids and 38.46% after giving calcium dobesilate therapy. These results were contradicting with results of the study conducted by Sarabia et al [12], which showed that there was no significant difference in efficacy of flavonoids (73%) and calcium dobesilate (76%) in hemorrhoidal disease. They stated that both drugs were equally effective and well tolerated [12].…”

“…These results were contradicting with results of the study conducted by Sarabia et al [12], which showed that there was no significant difference in efficacy of flavonoids (73%) and calcium dobesilate (76%) in hemorrhoidal disease. They stated that both drugs were equally effective and well tolerated [12]. In a study conducted by Alonso-Coello et al [7], flavonoids reduced the risk of bleeding and persisting symptoms by 67% and 58%, respectively.…”

Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well-known to be involved in pathology of vascular diseases and blood vessel weakness including hemorrhoid (Cai and Harrison, 2000). A mixture of flavonoids, particularly diosmin and hesperidin, is used as a reference drug for the treatment of an acute symptom of hemorrhoid (Sarabia et al, 2001) by increasing venous tone (Panthong et al, 2007) and modulating oxidative stress in various cell systems (Cypriani et al, 1993;Chiou et al, 2008).…”

Haemorrhoidal Disease Management

“…Three English language studies assessing the efficacy of calcium dobesilate in HD are available. Sarabia et al 38 conducted a double-blind, 4-week study of calcium dobesilate (1.5 g/day) versus the flavonoid fraction of diosmin (1.5 g twice a day) in 51 patients with acute episodes of HD. Blinding was maintained for the first 10 days and symptoms (pain, discharge, pruritus, oedema, inflammation, bleeding, and anal pressure) assessed at baseline Day 2, Day 8, and at 4 weeks.…”

“…In summary, the same efficacy was achieved with half the number of daily doses of calcium dobesilate compared with the active control. 38 In a 2-week randomised double-blind study, patients with Grade I or II HD received either calcium dobesilate (n=29) or a high fibre diet (n=16). Symptoms and anoscopic inflammation were scored on a scale from 0-2 at baseline and after treatment.…”