Calcium, Dairy Products, and Bone Health in Children and Young Adults: A Reevaluation of the Evidence

Lanou, Amy Joy; Berkow, Susan E.; Barnard, Neal D.

doi:10.1542/peds.2004-0548

Cited by 203 publications

(136 citation statements)

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“…In contrast, numerous reports have shown the negative impact of low intake of calcium/dairy products on girls' trabecular bone after menarche. (1)(2)(3)(4)(5)(6) Our results suggest that low vitamin D status [25(OH)D levels 40 nmol/L] may impair lumbar spine mineralization, even during the late-pubertal or postmenarcheal period, when associated with low calcium intake ( 600 mg/day). Age and pubertal maturation, height, and BMI are known to markedly influence lumbar spine area, BMC, and aBMD.…”

Section: Discussionmentioning

confidence: 77%

“…(1)(2)(3)(4)(5)(6) But data on a possible impact of low vitamin D status are less convincing. (7,8) Indeed, associations between low 25-hydroxyvitamin D [25(OH)D] levels, below 25 to 30 nmol/L (9) or 40 to 45 nmol/L, (10,11) and impaired bone mineralization have been observed at appendicular sites (ie, tibia and forearm) in girls during growth but not at trabecular bone sites (eg, hip, femoral neck, or lumbar spine) (9,12,13) or only during the early phase of puberty in severely vitamin D-deficient girls with 25(OH)D levels below 20 nmol/L.…”

Section: Introductionmentioning

confidence: 99%

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Adverse interaction of low-calcium diet and low 25(OH)D levels on lumbar spine mineralization in late-pubertal girls

Esterle

Nguyen

Walrant-Debray

et al. 2010

Journal of Bone and Mineral Research

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No consensus has been reached on the serum 25-hydroxyvitamin D [25(OH)D] levels required to ensure optimal bone health around menarche. We searched for a possible interaction of 25(OH)D levels and calcium intake on lumbar spine mineralization and on biologic features of bone metabolism in healthy late-pubertal girls. Lumbar spine parameters (ie, area, mineral content, and density) and calcium intake were evaluated in 211 healthy white adolescent girls at pubertal stages IV-V (11 to 16.9 years), together with biologic markers of calcium and bone metabolism and with International External Quality Assessment Scheme for Vitamin D Metabolite (DEQAS)-validated serum 25(OH)D levels. A high prevalence of 25(OH)D levels 30 nmol/L (41%), 40 nmol/L (61%), and 50 nmol/L (70%) was found during winter-spring. Parathyroid hormone (PTH) levels were inversely associated with 25(OH)D levels ( p ¼ .0021). In contrast, lumbar spine mineral content and density were not associated with 25(OH)D, excepted when calcium intake was below 600 mg/day ( p ¼ .0081). Girls with such low calcium intake and 25(OH)D levels of 40 nmol/L or less (9% of the cohort) had a 0.4 to 0.7 SD lower mean areal bone mineral density Z-score than girls with higher calcium intake and/or higher 25(OH)D status. The adverse association between lumbar spine mineralization and combined calcium deficiency-low 25(OH)D levels remained significant in the 91 girls who could be followed over 4 years after their initial evaluation. We conclude that low 25(OH)D levels ( 40 nmol/L) are observed frequently during winterspring in late-pubertal European girls, which may exacerbate the negative impact of calcium deficiency on lumbar spine mineralization. ß

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Adverse interaction of low-calcium diet and low 25(OH)D levels on lumbar spine mineralization in late-pubertal girls

Esterle

Nguyen

Walrant-Debray

et al. 2010

Journal of Bone and Mineral Research

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“…According to Huth et al (2006), the low intake of calcium by Americans and the large difference between recommended and typical dietary Ca intakes are recognized as major public health problems. In fact, low consumption of Ca has several effects on human health such as osteoporosis, which is more frequent in women than in men (e.g., Guéguen and Pointillart, 2000;Lanou et al, 2005;Devriese et al, 2006;Huth et al, 2006), arterial hypertension, colon cancer (Guéguen and Pointillart, 2000;Huth et al, 2006), and regulation of body weight and body fat (Huth et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Potential estimation of major mineral contents in cow milk using mid-infrared spectrometry

Soyeurt

Bruwier

Romnee

et al. 2009

Journal of Dairy Science

112

123

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Milk and dairy products are a major source of minerals, particularly calcium, involved in several metabolic functions in humans. Currently, several dairy products are enriched with calcium to prevent osteoporosis. The development of an inexpensive and fast quantitative analysis for minerals is required to offer dairy farmers an opportunity to improve the added value of the produced milk. The aim of this study was to develop 5 equations to measure Ca, K, Mg, Na, and P contents directly in bovine milk using mid-infrared (MIR) spectrometry. A total of 1,543 milk samples were collected between March 2005 and May 2006 from 478 cows during the Walloon milk recording and analyzed by MIR spectrometry. Using a principal component approach, 62 milk samples were selected by their spectral variability and separated in 2 calibration sets. Five outliers were detected and deleted. The mineral contents of the selected samples were measured by inductively coupled plasma atomic emission spectrometry. Using partial least squares combined with a repeatability file, 5 calibration equations were built to estimate the contents of Ca, K, Mg, Na, and P in milk. To assess the accuracy of the developed equations, a full cross-validation and an external validation were performed. The cross-validation coefficients of determination (R 2 cv) were 0.80, 0.70, and 0.79 for Ca, Na, and P, respectively (n = 57), and 0.23 and 0.50 for K and Mg, respectively (n = 31). Only Ca, Na, and P equations showed sufficient R 2 cv for a potential application. These equations were validated using 30 new milk samples. The validation coefficients of determination were 0.97, 0.14, and 0.88 for Ca, Na, and P, respectively, suggesting the potential to use the Ca and P calibration equations. The last 30 samples were added to the initial milk samples and the calibration equations were rebuilt. The R 2 cv for Ca, K, Mg, Na, and P were 0.87, 0.36, 0.65, 0.65, and 0.85, respectively, confirming the potential utilization of the Ca and P equations. Even if new samples should be added in the calibration set, the first results of this study showed the feasibility to quantify the calcium and phosphorus directly in bovine milk using MIR spectrometry.

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“…Une vaste méta-analyse sélectionnant 139 publications, réalisée en 2000 (5), conclut à l'effet bénéfique des produits laitiers sur la masse osseuse. En 2005 en revanche et de manière étonnante, alors même que la bibliographie est devenue plus riche, une autre méta-analyse ne retient que 37 publications, pour conclure à l'inefficacité (6). Elle est réalisée sous l'égide du PRCM (Physician Committee for Responsible Medicine: association qui fait la promotion aux USA de médecines alternatives, de régimes végétariens ou végétaliens), principalement constitué de non-médecins ou dépourvus d'attaches universitaires ou hospitalières.…”

Section: -Lait Et Pathologies : Utilisation Devoyee De Travaux Serunclassified

True and False Dangers of Milk and Milk Products

Bourre¹

2017

IJMS

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. Auteur, entre autres, aux éditions Odile Jacob de « Le lait, vrais et faux dangers » et récemment « La chrono-alimentation du cerveau ». RESUMEAucune classe d'aliment ne doit être négligée, car chacune offre des spécificités nutritionnelles, en termes de vitamines, oligoéléments, minéraux, acides aminés indispensables, acides gras oméga-3 et 6. Le lait et les produits laitiers ont donc leur place. Dans le cadre d'une alimentation diversifiée, leur présence assure une meilleure santé, ne serait-ce que par la réduction du risque de certaines pathologies. Le lait subit, depuis de très nombreuses années, des attaques qui sont le plus souvent injustifiées, intuitives ou pseudoscientifiques. Ainsi, les détracteurs du lait et des produits laitiers utilisent, globalement, deux séries d'arguments. L'une relève de l'utilisation erronée ou abusive de données scientifiques et médicales, épidémiologiques et statistiques : elle foisonne de propos pseudo-scientifiques. L'autre série d'assertions présente quelques allégations (parmi de nombreuses) qui ne reposent sur aucun support scientifique : on peut les qualifier de fantaisistes. Toutefois elles bénéficient malheureusement d'une certaine influence auprès des consommateurs. MOTS CLÉS :Lait, Produits Laitiers, Santé, Maladies. ABSTRACTNone of the food classes is to be neglected, as each presents nutritional specificities, in terms of vitamins, oligo elements, minerals, essential amino-acids, omege-3 and 6 polyunsaturated fatty acids. Milk and milk products occupy a specific place. In terms of a diversified diet, their presence ensure a better health, because the reduction of number of pathologies. Since nay years, milk suffer many attacks, most of them not justified, intuitive or pseudo-scientific. Thus, milk products and milk detractors, are using, globally, two line of arguments. One is using false or abusive scientific and medical data. The other presents arguments not at all based on scientific arguments, possibly qualified as fantasist. Unfortunately, consumer is interested by them.

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Calcium, Dairy Products, and Bone Health in Children and Young Adults: A Reevaluation of the Evidence

Abstract: Scant evidence supports nutrition guidelines focused specifically on increasing milk or other dairy product intake for promoting child and adolescent bone mineralization.

Cited by 203 publications

References 94 publications

Adverse interaction of low-calcium diet and low 25(OH)D levels on lumbar spine mineralization in late-pubertal girls

Adverse interaction of low-calcium diet and low 25(OH)D levels on lumbar spine mineralization in late-pubertal girls

Potential estimation of major mineral contents in cow milk using mid-infrared spectrometry

True and False Dangers of Milk and Milk Products

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