Calcium channels, transporters and exchangers in placenta: a review

Belkacemi, Louiza; Bédard, Isabelle; Simoneau, Lucie; Lafond, Julie

doi:10.1016/j.ceca.2004.06.010

Cited by 119 publications

(64 citation statements)

References 87 publications

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“…Fetal accretion of Ca 2+ increases exponentially over the last third of pregnancy, concomitant with the development of the fetal skeleton (Comar, 1956), suggesting that there is cross talk between the two processes. Data suggest that in the mouse and rat placenta, as in other epithelia, Ca 2+ transport is likely to involve three main steps (Atkinson et al, 2006;Belkacemi et al, 2005): firstly, diffusion into the trophoblast from maternal plasma down an electrochemical gradient through epithelial Ca 2+ channels of the transient receptor potential (TRP) gene family; secondly, transfer across the trophoblast cytoplasm bound to the calcium binding protein calbindin-D 9K (Glazier et al, 1992); and, thirdly, active extrusion into the fetal compartment via plasma membrane Ca 2+ -ATPase (PMCA) localized to the BM (Borke et al, 1989;Fisher et al, 1987). Over the last third of gestation, gene and protein expression for calbindin-D 9K increases markedly in both mouse and rat placenta Glazier et al, 1992;Hamilton et al, 2000;Mathieu et al, 1989) and correlates with the increase in unidirectional maternofetal 45 Ca clearance measured over the same period (Glazier et al, 1992), suggesting that transcytosolic transfer on this protein and the dynamic equilibrium between bound and free Ca 2+ in the syncytiotrophoblast might be the rate limiting step of transfer in these species.…”

Section: Ca 2+ Transportmentioning

confidence: 99%

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

145

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This review considers mechanisms by which transfer across the placenta takes place and how the capacity of the placenta to supply nutrients relates to fetal growth and vice versa. Blood flow through both uterine and umbilical circulations of the placenta, the structural properties of the placental exchange barrier and its related diffusional permeability, and the expression and activity of a wide range of transporter proteins in the syncytiotrophoblast, the transporting epithelium of the placenta, all need to be taken into account in considering placental supply capacity. We discuss the evidence that each of these factors affects, and is affected by, fetal growth rate and consider the regulatory mechanisms involved, with a particular focus on data that has emerged from study of the system A amino acid transporter. We consider that future work will build on the considerable foundation of knowledge regarding placental transfer mechanisms, as well as the other aspects of placental structure and function, to develop new diagnostic and therapeutic strategies for pregnancy complications, such as fetal growth restriction or overgrowth.

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Section: Ca 2+ Transportmentioning

confidence: 99%

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

145

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“…They are also expressed in the placenta and trophoblast and play an important role in the delivery of calcium to the foetus [189,190].Heavy metal cations, particularly lead and mercury, are potent calcium channel blockers but can also permeate these channels, gaining access to the cell [191]. The enrichment ratio and the total number of genes affected by each compound are shown after each compound name.…”

Section: Autism Genes Are Targeted By Relevant Hormones and Transmittmentioning

confidence: 99%

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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“…In mammalian intestine, the transcellular Ca 2+ transport system plays a crucial role in maintaining Ca 2+ homeostasis, which is a three-step process, comprising the passive entry of Ca 2+ into enterocytes via the transient receptor potential vanilloid channel type 5 or 6 (TRPV5, TRPV6); the cytosolic transfer of Ca 2+ bound to the protein calbindin D 9k (avian and other lower species' tissues contain calbindin D 28K ); and the extrusion of Ca 2+ across the basolateral membrane via Ca 2+ -ATPase (PMCA 1b) and/or a Na + -Ca 2+ exchanger (NCX 1b) (van Abel et al, 2005). A similar mechanism exists in tissues such as the kidney, uterus, and placenta (Belkacemi et al, 2005;Hirnet et al, 2003;Kim et al, 2006;Suzuki et al, 2008;Lee and Jeung, 2007).…”

Section: Introductionmentioning

confidence: 99%

Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens

Yang

Hou

Farquharson

et al. 2011

British Poultry Science

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In mammalian intestine, the passive entry of Ca 2+ into enterocytes via the transient receptor potential vanilloid channel type 6 (TRPV6) is recognized to be an important rate-limiting entry step in maintaining Ca 2+ homeostasis. There is, however, little information on the expression patterns of TRPV6 in the laying hen and therefore this study investigated TRPV6 localization and expression in different intestinal segments and kidney of laying hens during peak lay. Immunohistochemical analysis of the intestine indicated that TRPV6 was localized to the brush-border membranes of the duodenum, jejunum, ileum, cecum, and rectum. Expression was weaker in the rectum and little or no expression was found in crypt and goblet cells. In addition, TRPV6 mRNA was quantified amongst different intestinal segments and expression was highest in the duodenum and jejunum. Furthermore, western blotting indicated that the duodenum expressed the greatest amount of TRPV6 and the rectum the least with the other segments expressing intermediate levels. In the kidney, distinct immunopositive staining for TRPV6 was detected at the apical domain of the distal convoluted tubules (DCT) and medullary connecting tubules (CNT). Interestingly, distribution of TRPV6 extended to the proximal convoluted tubules (PCT), which is not generally implicated in active Ca 2+ transcellular reabsorption. Furthermore, the kidney expressed lower TRPV6 mRNA (P<0.05) and protein levels compared to duodenum possibly implicating an important role for the TRPV5 homolog in the kidney. In conclusion, the epithelial Ca 2+ channel TRPV6 is strongly expressed in the apical cells of the entire intestine and the renal tubules suggesting that active Ca 2+ transcellular transport plays a crucial role in dietary calcium (re)absorption in laying hens.

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Calcium channels, transporters and exchangers in placenta: a review

Cited by 119 publications

References 87 publications

Placental nutrient supply and fetal growth

Placental nutrient supply and fetal growth

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens

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