Calcium Channel, Ca++ mobilization, and Mechanical Reactivity of Estrogen- and Progesterone-Treated Rat Uterus

Abstract

Abstract-Properties of [3H]nitrendipine binding, high K' and Ca"-Induced contractions and the inhibition of high K+-induced contractions by verapamil were investigated in the uterine preparations isolated from rats treated with estrogen or progesterone or both.

Steroidal Regulation of Uterine Edema and Tissue Inhibitors of Metalloproteinase (TIMP)-3 Messenger RNA Expression Is Altered in TIMP-1-Deficient Mice1

“…However, recent accumulating evidence suggests that steroid hormones can elicit nongenomic actions within reproductive tissues [44]. Within the uterus, E 2 has been shown to stimulate calcium entry into endometrial cells [45] and tissue [46,47], and this mechanism is thought to play a role in normal uterine physiology. Pertinent to the current study is the observation that an increase in intracellular calcium has been associated with increases in MMP activity [48][49][50] and that MMPs themselves [51] can further increase calcium influx into cells.…”

Low dihydropyridine receptor density in vasa deferentia of castrated rats

“…A survey of severai drugs which might regulate the number and functioning of calcium channels has recently been presented (Ferrante & Triggle, 1990). The only references to the influence of sex hormones has been from the work of Ishii et al (1986), Batra (1987) and Ruzycky et al (1987) who reported that circulating oestrogens and progesterone can alter the binding characteristics of dihydropyridines in smooth muscle of female rats. However, to our knowledge, the possibility derived from the present results that male sex hormones also influence calcium channel regulation, has not been demonstrated previously.…”

A change in inhibitory mechanism of Na+ deficiency on high K+-induced contraction in rat uterus with the progress of pregnancy.

“…On the other hand, it has been reported that the high K+ induced contraction in rat uterus is under the influence of estrogen and progesteron (Ishii et al 1986, Takayama et al 1986, Uruno et al 1983. We have already reported that the decrease of the developed tension in isosmotically substituted high K+/Na+deficient solution in rat uterus of estrus phase is probably due to the cell swelling (Kamizaki et al 1988).…”