Calcium channel blockers: an update

Eisenberg, Mark J.; Brox, Anya C.; Bestawros, Alain

doi:10.1016/j.amjmed.2003.08.027

Cited by 155 publications

(96 citation statements)

References 70 publications

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“…with reduced PD risk (*30%). Given the short period of treatment in many cases (*2 years), variable dosing, and low relative affinity of DHPs for Cav1.3 calcium channels (compared to Cav1.2 channels) (28,67,73), this is a surprisingly strong association and lends further credence to the proposition that a BBB permeable and potent Cav1.3 antagonist could be a very effective neuroprotective agent. That said, these studies are not a substitute for a controlled clinical trial.…”

Section: Surmeier Et Almentioning

confidence: 99%

See 1 more Smart Citation

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

Surmeier

Guzmán

Sánchez-Padilla

et al. 2011

Antioxidants & Redox Signaling

135

109

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Parkinson's disease (PD) is a major world-wide health problem afflicting millions of the aged population. Factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated public discussions of disease etiology. Although there is compelling evidence supporting an association between disease risk and these factors, the pattern of neuronal pathology and cell loss is difficult to explain without cell-specific factors. This article focuses on recent studies showing that the neurons at greatest risk in PD-substantia nigra pars compacta dopamine neurons-have a distinctive physiological phenotype that could contribute to their vulnerability. The opening of L-type calcium channels during autonomous pacemaking results in sustained calcium entry into the cytoplasm of substantia nigra pars compacta dopamine neurons, resulting in elevated mitochondrial oxidant stress and susceptibility to toxins used to create animal models of PD. This cellspecific stress could increase the negative consequences of pan-cellular factors that broadly challenge either mitochondrial or proteostatic competence. The availability of well-tolerated, orally deliverable antagonists for L-type calcium channels points to a novel neuroprotective strategy that could complement current attempts to boost mitochondrial function in the early stages of the disease.

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Section: Surmeier Et Almentioning

confidence: 99%

“…These channels are antagonized by dihydropyridines (DHPs) that are approved for human use. DHPs have a very modest side-effect profile and have been used for decades to treat hypertension (28).…”

Section: Surmeier Et Almentioning

confidence: 99%

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

Surmeier

Guzmán

Sánchez-Padilla

et al. 2011

Antioxidants & Redox Signaling

135

109

View full text Add to dashboard Cite

show abstract

“…All L-type calcium channel blockers lower systolic and diastolic blood pressure by reducing peripheral vascular tone and improve blood supply to the heart by dilating coronary arteries. 32 However, dihydropyridine (DHP) and non-dihydropyridine (non-DHP) calcium channel blockers differ in their effect on cardiac contractility and heart rate ( Table 1). Non-DHP calcium channel blockers decrease contractility and heart rate; factors that decrease cardiac workload and are beneficial in patients suffering from angina, but are contra-indicated in patients with heart failure.…”

Section: Physiologymentioning

confidence: 99%

Cardiac ion channels

Priest

McDermott

2015

Channels

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Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time, off-target interactions of drugs with cardiac ion channels can be the cause of unwanted side effects. This manuscript aims to review the physiology and pharmacology of key cardiac ion channels. The intent is to highlight recent developments for therapeutic development, as well as elucidate potential mechanisms for drug-induced cardiac side effects, rather than present an in-depth review of each channel subtype.

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“…The extract produced vasodilatation in K + contracted aorta at much lower dose than required for vasodilatation of phenylephrine-contracted aorta preparation, indicating that the extract may be acting Vales are mean ± SEM of 4 determinations A through voltage-dependent Ca 2+ channels. Ca 2+ channel blockers constitute an important class of drugs used clinically in the management of hypertension and angina due to direct vasodilator and cardio depressant actions (Eisenberg et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Hypotensive and diuretic activities of aqueous-ethanol extract of Asphodelus tenuifolius

Aslam

Janbaz

Jabeen

2016

Bangladesh J Pharmacol

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In order to rationalize the traditional uses of Asphodelus tenuifolius in cardiovascular complaints, aqueous-ethanol extract of the plant was investigated for hypotensive and diuretic activities using in vivo and in vitro models. Intravenous administration of the extract in anesthetized rats produced 14.5 (95% CI; 13.3–15.6), 24.5 (95% CI; 21.3-27.9) and 35.3% (95% CI; 32.0–42.5) fall in mean arterial blood pressure at the doses of 3, 10 and 30 mg/kg, respectively. The extract increased the urine volume and electrolytes excretion significantly at the doses of 300 and 500 mg/kg in rats. In rabbit’s isolated aorta preparations, the extract, like verapamil, relaxed K+ (80 mM)-induced contractions more potently than phenylephrine (1 µM)–induced contractions, indicating Ca2+ antagonistic activity. The extract produced dose-dependent stimulant followed by depressant effects in spontaneously contracting rabbit’s paired atria preparations. The results suggest that the extract of A. tenuifolius has hypotensive and diuretic effects in animals.

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Calcium channel blockers: an update

Cited by 155 publications

References 70 publications

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

Cardiac ion channels

Hypotensive and diuretic activities of aqueous-ethanol extract of <i>Asphodelus tenuifolius</i>

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