Calcium Binding Proteins

Yáñez, Matilde; Gil‐Longo, José; Campos‐Toimil, Manuel

doi:10.1007/978-94-007-2888-2_19

Cited by 135 publications

(88 citation statements)

References 104 publications

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“…[28][29][30][31][32] Upon binding to calcium, C2 domain is known to bind to substrates such as phospholipids and intracellular proteins. 33,34 In silico analysis using NCBI-BLAST (http://www.ncbi.nlm.nih.gov/BLAST/) tool for multiple alignment of the entire CDPK1 and CDPK3 protein sequences with that of sequences obtained from NCBI's Protein tool (http://www.ncbi.nlm.nih.gov/protein) showed that there is a 52-57% identity to higher plants and, both the CDPKs show a maximum of 42% identity to apicomplexan protozoans. Of the 500 sequences that were obtained in this blast, 20 have been chosen that showed > 30% identity with the CDPK1 and CDPK3 and used to generate a Phylogenetic tree using MEGA6: Molecular Evolutionary Genetics Analysis version 6.0 software (Fig.…”

Section: Resultsmentioning

confidence: 99%

Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation

Motiwalla

Sequeira²,

D’Souza³

2014

Plant Signaling & Behavior

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Section: Resultsmentioning

confidence: 99%

Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation

Motiwalla

Sequeira²,

D’Souza³

2014

Plant Signaling & Behavior

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“…Local regulation of Ca 2+ controls selective and spatially restricted specific processes [33], avoids toxicity and keeps energetic costs for re-establishing homeostasis low. For the latter purpose, some high capacity/low affinity CaBPs are also present in the cytosol [34].…”

Section: From Bacteria To the Eukaryote Cell: Requirement Of Ca 2+ Fomentioning

confidence: 99%

The ancient roots of calcium signalling evolutionary tree

Plattner¹,

Verkhratsky²

2015

Cell Calcium

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Molecular cascades of calcium homeostasis and signalling (Ca(2+) pumps, channels, cation exchangers, and Ca(2+)-binding proteins) emerged in prokaryotes and further developed at the unicellular stage of eukaryote evolution. With progressive evolution, mechanisms of signalling became diversified reflecting multiplication and specialisation of Ca(2+)-regulated cellular activities. Recent genomic analysis of organisms from different systematic positions, combined with proteomic and functional probing invigorated expansion in our understanding of the evolution of Ca(2+) signalling. Particularly impressive is the consistent role of Ca(2+)-ATPases/pumps, calmodulin and calcineurin from very early stages of eukaryotic evolution, although with interspecies differences. Deviations in Ca(2+) handling and signalling are observed between vertebrates and flowering plants as well as between protists at the basis of the two systematic categories, Unikonta (for example choanoflagellates) and Bikonta (for example ciliates). Only the B-subunit of calcineurin, for instance, is maintained to regulate highly diversified protein kinases for stress defence in flowering plants, whereas the complete dimeric protein, in vertebrates up to humans, regulates gene transcription, immune-defence and plasticity of the brain. Calmodulin is similarly maintained throughout evolution, but in plants a calmoldulin-like domain is integrated into protein kinase molecules. The eukaryotic cell has inherited and invented many mechanisms to exploit the advantages of signalling by Ca(2+), and there is considerable overall similarity in basic processes of Ca(2+) regulation and signalling during evolution, although some details may vary.

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“…32 Calcium ions are used to carry cellular signals and as transporters across cell membranes. 33,34 They also regulate intracellular mechanisms by binding to proteins. The cellular level of Ca 2+ is precisely regulated -a significant increase in the calcium level can lead to apoptotic changes.…”

Section: +mentioning

confidence: 99%

Venous insufficiency: Differences in the content of trace elements. A preliminary report

Rusak¹,

Karuga-Kuźniewska²,

Wiatrak³

et al. 2018

Adv Clin Exp Med

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Background. Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Our results show that insufficient veins have different levels of some trace elements: magnesium, calcium, manganese, and silicon compared to control samples. This study could lead to a better understanding of the molecular causes of venous insufficiency and may help to develop better methods of treatment.

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Calcium Binding Proteins

Cited by 135 publications

References 104 publications

Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation

Two Calcium-Dependent Protein Kinases fromChlamydomonas reinhardtiiare transcriptionally regulated by nutrient starvation

The ancient roots of calcium signalling evolutionary tree

Venous insufficiency: Differences in the content of trace elements. A preliminary report

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