2004
DOI: 10.1074/jbc.m309617200
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Calcium-binding Protein 1 Is an Inhibitor of Agonist-evoked, Inositol 1,4,5-Trisphosphate-mediated Calcium Signaling

Abstract: Calcium is a ubiquitous intracellular second messenger in all vertebrate cells (1). Intracellular resting free Ca 2ϩ concentration ([Ca 2ϩ ] i ) is acutely maintained at around 100 nM via a variety of mechanisms, and even small local rises above this base line are able to elicit dramatic cellular responses. Rises in [Ca 2ϩ ] i are generated through two primary routes (2). First, many physiological agonists activate Ca 2ϩ channels that mediate the direct entry of extracellular Ca 2ϩ . Second, [Ca 2ϩ ] i can b… Show more

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Cited by 117 publications
(140 citation statements)
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“…Although this is still controversial (24,30), we have envisaged the hypothesis that CaBP1 could activate IP 3 R after complete removal of CaM from the IP 3 R. However, we did not observe any activation by CaBP1 alone or potentiation of IICR after removal of the endogenously bound CaM. This indicates that the N-terminal CaM-binding site that is also used by CaBP1 (24) is not involved in this process.…”
Section: Remains Unclear Exogenous Cam Inhibits Iicr In a Camentioning
confidence: 39%
“…Although this is still controversial (24,30), we have envisaged the hypothesis that CaBP1 could activate IP 3 R after complete removal of CaM from the IP 3 R. However, we did not observe any activation by CaBP1 alone or potentiation of IICR after removal of the endogenously bound CaM. This indicates that the N-terminal CaM-binding site that is also used by CaBP1 (24) is not involved in this process.…”
Section: Remains Unclear Exogenous Cam Inhibits Iicr In a Camentioning
confidence: 39%
“…Both His-and Flag-tagged rBcl-X L , generated using distinct purification protocols, were equally effective, whereas His-tagged NCS-1, which does not interact with InsP 3 R (ref. 32), had no effect either alone or in combination with 10 nM InsP 3 (data not shown). Supplementary Information, Fig.…”
Section: Supplementary Materialsmentioning
confidence: 87%
“…There are reports of IP 3 -independent activation of IP 3 R by CaBP1 (Yang et al 2002), a member of the neuronal Ca 2þ -sensor family, and by Gbg subunits (Zeng et al 2003), but the physiological relevance is unclear (Haynes et al 2004;Nadif Kasri et al 2004). The current consensus is that binding of IP 3 to the IP 3 R is essential for its activation, but whether all four IP 3 -binding sites of the tetrameric IP 3 R must be occupied is unresolved.…”
Section: Regulation Of Ip 3 Receptors By Ca 2þ and Ipmentioning
confidence: 99%