Calcium and Inorganic Phosphate Transport in Rat Colon

Lee, D. B. N.; Walling, Marlin W.; Gafter, Uzi; Silis, V.; Coburn, Jack W.

doi:10.1172/jci109796

Cited by 55 publications

(17 citation statements)

References 19 publications

(21 reference statements)

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“…Some studies have shown a balance between true absorption and calcium secretion in the caecum (Petith and Schedl, 1976 ;Harrison and Harrison, 1969 ;Favus et al, 1980 ;Favus, Kathpalia and Coe, 1981 ;Lee et al, 1980). The present study agrees with the results of Cramer (1951) who reported significant phosphorus absorption in the terminal intestine of CV rats.…”

Section: Introductionsupporting

confidence: 93%

Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Andrieux¹,

Sacquet²

1983

Reprod. Nutr. Dévelop.

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Summary. For 4 weeks, 3-month old germfree (GF) and conventional (CV) rats were given a semi-synthetic diet sterilized by irradiation with or without 10 % of lactose. During the 5th week, 0.2 % of titanium oxide (Ti0 2 ) was added to the diet and the rats were killed at regular intervals throughout the light/dark cycle. The patterns of Tio 2 and 'Ca excretion were similar, indicating that Tio 2 was a good marker of unabsorbed calcium transit. The apparent absorption coefficient of calcium, magnesium and phosphorus was determined in the ileum, caecum, large intestine and faeces by the mineral/Tio 2 ratio. The effects of microflora and lactose varied with the mineral and the digestive tract level studied. -In the small intestine, microflora had no effect on the apparent absorption of calcium and magnesium but did have an unfavorable influence on phosphorus absorption. Lactose increased calcium and magnesium absorption, and this increase was similar in GF and CV rats, but lactose had a favorable effect on phosphorus absorption only in CV rats. -In the caecum, microflora had an unfavorable effect on the apparent absorption of calcium and magnesium and a favorable effect on phosphorus absorption. The ingestion of lactose reduced calcium and magnesium absorption in the caecum of GF rats and phosphorus absorption in the caecum of CV animals.In the colon, mineral absorption was not significant in either CV or GF rats receiving the lactose-free diets. Lactose ingestion caused the absorption of calcium, magnesium and phosphorus to rise significantly only in GF rats. This absorption contributed to the stronger effect of lactose on total calcium and phosphorus absorption in GF rats.Introduction.

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Section: Introductionsupporting

confidence: 93%

Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Andrieux¹,

Sacquet²

1983

Reprod. Nutr. Dévelop.

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“…1,25-Dihydroxyvitamin D ( 1,25D) repletion in these rats caused the induction of active Pi absorption in the duodenum and marked augmentation of active Pi absorption in the jejunum ( 1-3). Little or no active Pi absorption, in both -D and 1,25D-replete rats, was noted in the ileum ( 1) and the colon (4). These and similar findings by others (5) have led to the consensus that the bulk of Pi absorption is accomplished in the proximal intestine (6).…”

Section: Introductionmentioning

confidence: 51%

Analysis of segmental phosphate absorption in intact rats. A compartmental analysis approach.

Kayne¹,

D’Argenio²,

Jh³

et al. 1993

J. Clin. Invest.

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“…In rats active absorption is virtually confined to the duodenum and jejunum, whereas in mice it occurs throughout the ileum [36,37,38]. This difference between species makes it difficult to extrapolate to man, but the few studies available suggest that in man phosphate absorption resembles that in the rat more closely than in the mouse [38].…”

Section: Anion Concentrations In the Gastrointestinal Tractmentioning

confidence: 99%

Sevelamer and Other Anion-Exchange Resins in the Prevention and Treatment of Hyperphosphataemia in Chronic Renal Failure

Wrong

Harland²

2007

Nephron Physiol

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Sevelamer, or more precisely ‘sevelamer hydrochloride’, is a weakly basic anion-exchange resin in the chloride form that was introduced in 1997 for the treatment of the hyperphosphataemia of patients with end-stage renal failure, usually those on long-term haemodialysis. The rationale for this therapy was that sevelamer would sequester phosphate within the gastrointestinal tract, so preventing its absorption and enhancing its faecal excretion. Over the succeeding years, large numbers of patients have been treated with sevelamer, and it has fulfilled expectations in helping to control the hyperphosphataemia of end-stage renal failure. However, it is only one of many anion-exchange resins that could be used for this purpose, some of which are currently available for clinical use and are much less costly than sevelamer. Theoretical considerations suggest that some of these other resins might be at least as efficient as sevelamer in sequestering phosphate in the gastrointestinal tract. Neither sevelamer, nor any of these other agents, has been submitted to a proper metabolic balance study to measure the amount of phosphate sequestered by the resin in the bowel, and without this information it is impossible to judge which is the ideal resin for this purpose.

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Calcium and Inorganic Phosphate Transport in Rat Colon

Cited by 55 publications

References 19 publications

Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat

Analysis of segmental phosphate absorption in intact rats. A compartmental analysis approach.

Sevelamer and Other Anion-Exchange Resins in the Prevention and Treatment of Hyperphosphataemia in Chronic Renal Failure

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