Calcitonine et peptides apparentés

Cohen, R.; Becker, Kenneth L.; Jullienne, A.

doi:10.1016/j.emcend.2004.07.001

Cited by 4 publications

(1 citation statement)

References 106 publications

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“…In humans, CT is also predominantly found in the lungs [63,64]. Similarly, chicken CT is highly expressed in the lungs and may exert paracrine effects within the lung tissue by modulating intracellular and transcellular calcium movements [65]. Interestingly, in chickens, the expression of CT in the ovaries hints at a potentially more prominent role in reproduction compared to mammals, as it is expressed in granulosa cells and follicle membrane cells, potentially regulating follicular maturation [61].…”

Section: Discussionmentioning

confidence: 99%

Functional Analysis and Tissue-Specific Expression of Calcitonin and CGRP with RAMP-Modulated Receptors CTR and CLR in Chickens

Huang,

Su,

Wang

et al. 2024

Animals

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Calcitonin (CT) and calcitonin gene-related peptide (CGRP) are critical regulators of calcium balance and have extensive implications for vertebrate physiological processes. This study explores the CT and CGRP signaling systems in chickens through cloning and characterization of the chicken calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR), together with three receptor activity-modifying proteins (RAMPs). We illuminated the functional roles for chickens between the receptors examined alone and in RAMP-associated complexes using luciferase reporter assays. Chicken CTRs and CLRs stimulated the cAMP/PKA and MAPK/ERK signaling pathways, signifying their functional receptor status, with CT showing appreciable ligand activity at nanomolar concentrations across receptor combinations. Notably, it is revealed that chicken CLR can act as a functional receptor for CT without or with RAMPs. Furthermore, we uncovered a tissue-specific expression profile for CT, CGRP, CTR, CLR, and RAMPs in chickens, indicating the different physiological roles across various tissues. In conclusion, our data establish a clear molecular basis to reveal information on CT, CGRP, CTR, CLR, and RAMPs in chickens and contribute to understanding the conserved or divergent functions of this family in vertebrates.

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Section: Discussionmentioning

confidence: 99%

Functional Analysis and Tissue-Specific Expression of Calcitonin and CGRP with RAMP-Modulated Receptors CTR and CLR in Chickens

Huang,

Su,

Wang

et al. 2024

Animals

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Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Lafont

Wang

Chen

et al. 2010

Journal of Bone and Mineral Research

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Calcitonin (CT) is one of the hormones involved in vertebrate calcium regulation. It has been proposed to act as a hypocalcemic factor, but the regulatory pathways remain to be clarified. We investigated the CT/calcitonin gene-related peptide (CGRP) family in zebrafish and its potential involvement in calcium homeostasis. We identified the presence of four receptors: CTR, CRLR1, CRLR2, and CRLR3. From the phylogenetic analysis, together with the effect observed after CT and CGRP overexpression, we concluded that CTR appears to be a CT receptor and CRLR1 a CGRP receptor. The distribution of these two receptors shows a major presence in the central nervous system and in tissues involved in ionoregulation. Zebrafish embryos kept in high-Ca 2þ -concentration medium showed upregulation of CT and CTR expression and downregulation of the epithelial calcium channel (ECaC). Embryos injected with CT morpholino (CALC MO) incubated in high-Ca 2þ medium, showed downregulation of CTR together with upregulation on ECaC mRNA expression. In contrast, overexpression of CT cRNA induced the downregulation of ECaC mRNA synthesis, concomitant with the downregulation in the calcium content after 30 hours postfertilization. At 4 days postfertilization, CT cRNA injection induced upregulation of hypercalcemic factors, with subsequent increase in the calcium content. These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis. ß

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Evolution of the CT/CGRP family: Comparative study with new data from models of teleosts, the eel, and cephalopod molluscs, the cuttlefish and the nautilus

Lafont

Dufour

Fouchereau-Péron

2007

General and Comparative Endocrinology

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Calcitonine et peptides apparentés

Cited by 4 publications

References 106 publications

Functional Analysis and Tissue-Specific Expression of Calcitonin and CGRP with RAMP-Modulated Receptors CTR and CLR in Chickens

Functional Analysis and Tissue-Specific Expression of Calcitonin and CGRP with RAMP-Modulated Receptors CTR and CLR in Chickens

Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Evolution of the CT/CGRP family: Comparative study with new data from models of teleosts, the eel, and cephalopod molluscs, the cuttlefish and the nautilus

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