Evolution of the CT/CGRP family: Comparative study with new data from models of teleosts, the eel, and cephalopod molluscs, the cuttlefish and the nautilus

Lafont, Anne-Gaëlle; Dufour, Sylvie; Fouchereau-Péron, Martine

doi:10.1016/j.ygcen.2007.01.027

Cited by 20 publications

(17 citation statements)

References 119 publications

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“…This peptide can interact with CTR in bones, lungs, kidney, the gastrointestinal tract, and the central nervous system (CNS). (9,36,37) In sauropsids, specific CT receptors have been identified in organs related to calcium regulation, such as the shell gland and the kidneys. (38,39) Very little information exists on CTR in teleosts, especially its tissue distribution.…”

Section: Discussionmentioning

confidence: 99%

“…(44)(45)(46) CGRP appears to play a similar role as neuromediator or neuromodulator in sauropsids and amphibians. (37) In the European eel, a phylogenetically ancient species among teleosts, CGRP was described to have an autocrine/ paracrine action in the central nervous system. (20,37) In zebrafish, the function of CGRP in the CNS seems to be local paracrine action, with the presence of both the peptide and its receptor.…”

Section: Discussionmentioning

confidence: 99%

“…(37) In the European eel, a phylogenetically ancient species among teleosts, CGRP was described to have an autocrine/ paracrine action in the central nervous system. (20,37) In zebrafish, the function of CGRP in the CNS seems to be local paracrine action, with the presence of both the peptide and its receptor. In vertebrates, the autocrine/paracrine function of CGRP in the CNS appears to be conserved among species.…”

Section: Discussionmentioning

confidence: 99%

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Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Lafont

Wang

Chen

et al. 2010

Journal of Bone and Mineral Research

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Calcitonin (CT) is one of the hormones involved in vertebrate calcium regulation. It has been proposed to act as a hypocalcemic factor, but the regulatory pathways remain to be clarified. We investigated the CT/calcitonin gene-related peptide (CGRP) family in zebrafish and its potential involvement in calcium homeostasis. We identified the presence of four receptors: CTR, CRLR1, CRLR2, and CRLR3. From the phylogenetic analysis, together with the effect observed after CT and CGRP overexpression, we concluded that CTR appears to be a CT receptor and CRLR1 a CGRP receptor. The distribution of these two receptors shows a major presence in the central nervous system and in tissues involved in ionoregulation. Zebrafish embryos kept in high-Ca 2þ -concentration medium showed upregulation of CT and CTR expression and downregulation of the epithelial calcium channel (ECaC). Embryos injected with CT morpholino (CALC MO) incubated in high-Ca 2þ medium, showed downregulation of CTR together with upregulation on ECaC mRNA expression. In contrast, overexpression of CT cRNA induced the downregulation of ECaC mRNA synthesis, concomitant with the downregulation in the calcium content after 30 hours postfertilization. At 4 days postfertilization, CT cRNA injection induced upregulation of hypercalcemic factors, with subsequent increase in the calcium content. These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis. ß

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Lafont

Wang

Chen

et al. 2010

Journal of Bone and Mineral Research

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“…The calcitonin family of peptides comprises calcitonin, amylin, two CGRPs, and adrenomedullin [28]. The original function of CGRP was thought to be the maintenance of vascular homeostasis, although it has been speculated that throughout evolution it acquired a new and more important role of nociceptive transmission [29].…”

Section: The Moleculementioning

confidence: 99%

Targeting CGRP: A New Era for Migraine Treatment

Goldberg

Silberstein

2015

CNS Drugs

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Migraine is a highly prevalent headache disease that typically affects patients during their most productive years. Despite significant progress in understanding the underlying pathophysiology of this disorder, its treatment so far continues to depend on drugs that, in their majority, were not specifically designed for this purpose. The neuropeptide calcitonin gene-related peptide (CGRP) has been indicated as playing a critical role in the central and peripheral pathways leading to a migraine attack. It is not surprising that drugs designed to specifically block its action are gaining remarkable attention from researchers in the field with, at least so far, a safe risk profile. In this article, we highlight the evolution from older traditional treatments to the innovative CGRP target drugs that are revolutionizing the way to approach this debilitating neurological disease. We provide a brief introduction on pathophysiology of migraine and details on the characteristic, function, and localization of CGRP to then focus on CGRP receptor antagonists (CGRP-RAs) and CGRP monoclonal antibodies (CGRP mAbs). Key PointsThe neuropeptide calcitonin gene-related peptide (CGRP) has been indicated as playing a critical role in the central and peripheral pathways leading to a migraine attack.Targeting CGRP as a specific therapeutic tool for migraine may offer similar or even better efficacy than currently available treatments without the vasoconstrictive risk factors.Further studies are necessary to determine the exact role of CGRP receptor antagonists and CGRP monoclonal antibodies in migraine with aura, allodynia, and photophobia.

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“…In mammals, the mRNA synthesis of two hormones is controlled by tissue-specific alternative splicing; CGRP precursor mRNA is synthesized in the neural tissues; CT precursor mRNA is synthesized in the thyroidal C-cells (Rosenfeld et al, 1983). Since CGRP exists widely in the central nervous system (Rosenfeld et al, 1983;Gibson et al, 1984), it is suggested that CGRP plays role as a neuromediator or neuromodulator (Lafont et al, 2007). In addition, CGRP is synthesized in the heart and blood vessels to control blood flow by its potent vasodilatory actions (Mulderry et al, 1985;Wimalawansa, 1997;Brain and Grant, 2004).…”

Section: Introductionmentioning

confidence: 99%

Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation

Suzuki

Sekiguchi

Satake

et al. 2012

Gene

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In cartilaginous fish, two cDNAs encoding calcitonin-family receptors were isolated for the first time from the stingray brain. The open reading frame of one receptor cDNA coded a 525-amino acid protein. The amino acid identity of this receptor to human calcitonin-receptor-like receptor (CRLR) is 64.5%, frog CRLR is 64.7%, and flounder CRLR is 61.2% and this was higher than to human calcitonin receptor (CTR) (46.1%), frog CTR (54.7%), and flounder CTR (48.9%). We strongly suggested that this receptor is a ray CRLR based on phylogenetic analysis. In case of the second receptor, amino acid identity among CRLRs (human 50.5%; frog 50.7%; flounder 48.0%) and CTRs (human 43.2%; frog 49.1%; flounder 41.8%) was similar. From phylogenetic analysis of both CRLRs and CTRs, we believe that this receptor is ray CTR. The expression of ray CRLR mRNA was predominantly detected in the nervous system (brain) and vascular system (atrium, ventricle, and gill), which reflects the similar localization of CGRP in the nervous and vascular systems as mammals. It was observed that the second receptor was expressed in several tissues, namely cartilage, brain, pituitary gland, gill, atrium, ventricle, pancreas, spleen, liver, gall bladder, intestine, rectal gland, kidney, testis and ovary. This localization pattern was very similar to flounder CTR. Both receptor mRNAs were strongly expressed in the gill. This suggests that the calcitonin-family members are involved in the osmoregulation of stingray as this fish is known to be euryhaline. When a stingray was transferred to diluted seawater (20% seawater), the expression of both receptors significantly decreased in the gill. Similar results were obtained in the kidney of the stingray. Thus, our cloning and isolation of both receptors in the stingray will be helpful for elucidation of their physiological role (s) such as osmoregulation including calcium metabolism of cartilaginous fish.3

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Evolution of the CT/CGRP family: Comparative study with new data from models of teleosts, the eel, and cephalopod molluscs, the cuttlefish and the nautilus

Cited by 20 publications

References 119 publications

Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)

Targeting CGRP: A New Era for Migraine Treatment

Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: Possible physiological roles of the calcitonin family in osmoregulation

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