Calcitonin reduces feeding in man, monkey and rat

Perlow, Mark J.; Freed, William J.; Carman, John S.; Wyatt, Richard Jed

doi:10.1016/0091-3057(80)90196-3

Cited by 91 publications

(12 citation statements)

References 40 publications

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“…It is known that CCK and bombesin stimulate the release of calcitonin from the thyroid gland after meals and calcitonin is a highly potent, long-acting suppressor of food intake. This was discovered by Freed et al in 1979 and corroborated by others (Knoll, 1980 a;Perlow et aL, 1980;Levine and Morley, 1981). As there are highly specific calcitonin receptors in the brain (Rizzo and Goltzman, 1981) and this peptide is also released in brain tissue, an involvement of calcitonin in the physiological regulation of feeding, by acting locally on the hypothalamic control of food intake, cannot be excluded.…”

Section: Endogenous Anorectic Substances In Comparison To Satietinsupporting

confidence: 53%

Satietin; a 50,000 dalton glycoprotein in human serum with potent, long-lasting and selective anorectic activity

Knoll

1984

J. Neural Transmission

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Satietin, a 50,000 dalton anorectic glycoprotein was isolated from human serum. Its isoelectric point is 7.0. It contains 14-15% amino acids and 70-75% carbohydrates. Its biological activity survives digestion with proteases and boiling. Satietin is a highly potent anorectic substance. The intracerebroventricular administration of 10-20 micrograms satietin suppresses food intake in rats during the first day of feeding after deprivation of food for 96 hours to half of the amount eaten by untreated controls (ID50). The onset of the effect can be detected within 30 minutes, the peak effect is reached within an hour. The effect lasts 24-30 hours. Satietin acts both at intravenous and subcutaneous administration (ID50 = 0.5-0.75 mg/kg) in rats deprived of food for 96 hours. The peak effect is reached within an hour and lasts over 24 hours. In contrast to the anorectic drugs in clinical use and to the endogenous anorectic substances (like cholecystokinin and calcitonin) satietin proved to be highly selective in suppressing food intake. Considering that satietin is widely distributed in the world of vertebrates, its concentration in the blood is amazingly high, its site of effect is in the central nervous system and it induces satiety without having any other detectable central or peripheral effect, the hypothesis was forwarded that satietin may play the role of a rate limiting blood-borne satiety signal in the negative feedback of food intake, i.e. serving as the essential chemical link connecting the gastrointestinal tract and the brain in the regulation of feeding.

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Section: Endogenous Anorectic Substances In Comparison To Satietinsupporting

confidence: 53%

Satietin; a 50,000 dalton glycoprotein in human serum with potent, long-lasting and selective anorectic activity

Knoll

1984

J. Neural Transmission

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“…The anorectic effect of salmon calcitonin (sCT) was first reported by Freed et al (1,2). When injected subcutaneously, the fish hormone strongly reduced food intake in rats and rhesus monkeys and reduced the body potency by direct injection into rat brain has led them to suggest that the peptide would exert its effect by directly acting on the central nervous system.…”

mentioning

confidence: 99%

Calcitonin-induced anorexia in rats: A structure-activity study by intraventricular injections.

et al. 1982

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Abstract-The anorectic potency of salmon, porcine and human calcitonins (sCT, pCT and hCT, respectively) and two sCT-fragments were compared in rats. Intraventricular injections of sCT (0.062 and 0.031 nmole/animal) significantly reduced the normal feeding and body weight. The effect appeared to be dose-dependent, reversible and lasted longer than 6 hr. No anorexia ensued, however, on injections of mammalian hormones though tested in relatively high doses (pCT: up to 3.7 nmole, hCT: 3.7 nmole). The C-terminal fragments of sCT, sCT (10-32) and sCT (22-32) were also found to be devoid of anorectic activity; but when administered with sCT, the longer fragment (1.2 nmole) significantly decreased the effect of sCT and even the shorter one (18 nmole) tended to act as an antagonist. This property was not recorded with pCT and hCT in the doses examined. On the one hand, these results indicate a novel specificity of the anorectic receptor in rat brain; and on the other hand, they seem to strongly argue against the hypothesis that in mammals thyroidal calcitonin secreted postprandially might participate in the regulation of subsequent feeding, unless the presence of the sCT-like molecule can be detected in mammals. All the more because detection of such a molecule must await development of a specific assay, the antagonistic property of the sCT fragment found herein would have use for clarifying the physiological significance of the anorectic receptor which is possibly in the hypothalamus.The anorectic effect of salmon calcitonin (sCT) was first reported by Freed et al. (1, 2). When injected subcutaneously, the fish hormone strongly reduced food intake in rats and rhesus monkeys and reduced the body potency by direct injection into rat brain has led them to suggest that the peptide would exert its effect by directly acting on the central nervous system. Later, using a synthetic derivative of eel calcitonin, Miyahara and Oomura (3) electrophysiologically identified a group of glucose-sensitive neurons in the rat hypothalamus as a possible locus of the anorectic effect. Since it has been demon strated that the calcitonin-like immuno activity increases postprandially in adult and

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“…In that study, the food intake of rhesus monkeys was suppressed for 3 days following a single high dose of sCT (6 g/kg) (30). The aim of our study was to determine the dose range of sCT that would affect food intake and meal patterns in nonhuman primates.…”

mentioning

confidence: 99%

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello

Kemm

Moran³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Calcitonin reduces feeding in man, monkey and rat

Cited by 91 publications

References 40 publications

Satietin; a 50,000 dalton glycoprotein in human serum with potent, long-lasting and selective anorectic activity

Satietin; a 50,000 dalton glycoprotein in human serum with potent, long-lasting and selective anorectic activity

Calcitonin-induced anorexia in rats: A structure-activity study by intraventricular injections.

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

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