Calcitonin Production and the Mitochondrion-Rich Cells of the Dog Thyroid

Foster, G. V.; MacIntyre, I.; Pearse, A. G. E.

doi:10.1038/2031029a0

Cited by 210 publications

(41 citation statements)

References 6 publications

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“…The present experiments on the dog seem to support strongly the hypothesis that the parafollicular cells of the thyroid gland are responsible for the secretion of the serum calcium lowering factor, thyrocalcitonin (FOSTER et al, 1964;PEARSE, 1966;MATSUZAWA, 1966;BUSSOLATI and PEARSE, 1967;KRACHT et al, 1968). Significant increase of the mitotic parafollicular cells in dogs was observed in this study after long-term administration of calcium and vitamine D3.…”

Section: Discussionsupporting

confidence: 84%

Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

Kameda

1970

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionsupporting

confidence: 84%

Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

Kameda

1970

Arch. Histol. Jap., Arch. Histol. Jpn

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“…Foster. Macintyre and pearse (1964) and Pearse (1965) suggested that thyrocalcitonin was synthesized by the parafollicular cells of the thyroid, and Pearse (1966) introduced the term C cells (C for calcitonin) for these cells. In a study of the embryology of the C cells.…”

Section: Chaptermentioning

confidence: 99%

In Vitro Biosynthesis of Calcitonin

Sorgente

L'Heureux

1971

Experimental Biology and Medicine

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“…Calcitonin (CT), a 32-amino acid peptide, is synthesized by the C cells of mammalian thyroid gland (Copp et al 1962, Foster et al 1964 and ultimobranchial gland of nonmammalian vertebrates (Copp et al 1967). The classic concept of CT function in mammals has focused on its effects on calcium homeostasis (Azria 1989).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of salmon calcitonin on secretion of 17β-estradiol by the ovarian follicles of common carp, Cyprinus carpio

Paul

Mukherjee²,

Pramanick³

et al. 2007

Journal of Endocrinology

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The effects of salmon calcitonin (sCT) on the secretion of 17b-estradiol (E 2 ) were examined in female common carp, Cyprinus carpio. Vitellogenic stage fish adapted to high-Ca water were i.p. injected with vehicle, sCT, human chorionic gonadotropin (hCG), or hCG plus sCT. To determine whether ovarian follicles are equipped with CT receptors, a CT binding assay was conducted. In the in vitro experiments, vitellogenic follicles were incubated with stimulators and inhibitors. Administration of sCT increased the basal and hCG-stimulated E 2 release in vivo and in vitro. Binding characteristics of [ 125 I]sCT to plasma membrane preparation of carp ovarian follicles showed saturability with high-affinity (K d Z48 . 48 pmol/l and B max Z1 . 2 pmol/mg protein). To clarify the mechanism of E 2 production by sCT, in vitro effect of sCT and hCG on aromatase activity (conversion of testosterone to E 2 ) and cytochrome P450 aromatase (P450arom) gene expression in carp ovarian follicles were investigated. Salmon CT-stimulated both aromatase activity and P450arom gene expression in ovarian follicles of carp. sCT-stimulated E 2 release by the ovarian follicles in vitro was augmented in the presence of dibutyryl cAMP. Inhibitor of protein kinase A (PKA), SQ 22536 inhibited sCT-stimulated steroid production in a dose-dependent manner. Specific inhibitor of protein kinase C (PKC), NPC-15437 dihydrochloride had no inhibitory effects on sCT-induced E 2 release. The present study indicates that sCT binds specifically to carp ovary and stimulates E 2 production by increasing the activity of cytochrome P450 aromatase and P450arom gene expression. The results further suggest that stimulatory action of sCTon E 2 production is mediated through cAMP pathway.

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Calcitonin Production and the Mitochondrion-Rich Cells of the Dog Thyroid

Cited by 210 publications

References 6 publications

Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

In Vitro Biosynthesis of Calcitonin

Stimulation of salmon calcitonin on secretion of 17β-estradiol by the ovarian follicles of common carp, Cyprinus carpio

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